利用金纳米颗粒给药

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2024-11-29 DOI:10.1016/j.addr.2024.115481

Lev Dykman , Boris Khlebtsov , Nikolai Khlebtsov

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引用次数: 0

摘要

现代纳米技术为有效地将药物输送到生物靶点提供了多种可能性。本文综述了功能化金纳米颗粒（GNPs）作为给药平台的研究进展。由于其特殊的尺寸和表面特性，GNPs是一种完美的靶向和选择性分配药物的载体。几项体外和体内试验表明，定制这些颗粒，将化学药物直接施用于肿瘤是多么简单。GNP表面也可以涂覆配体以修饰药物释放或提高选择性。此外，利用颗粒的光热特性可以增强药理学活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Drug delivery using gold nanoparticles

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Drug delivery using gold nanoparticles

Modern nanotechnologies provide various possibilities for efficiently delivering drugs to biological targets. This review focuses on using functionalized gold nanoparticles (GNPs) as a drug delivery platform. Owing to their exceptional size and surface characteristics, GNPs are a perfect drug delivery vehicle for targeted and selective distribution. Several in vitro and in vivo tests have shown how simple it is to tailor these particles to administer chemical medications straight to tumors. The GNP surface can also be coated with ligands to modify drug release or improve selectivity. Moreover, the pharmacological activity can be enhanced by using the photothermal characteristics of the particles.

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.