精准健康管理结合双能量骨密度仪治疗对老年骨质疏松症患者骨生物标志物的影响。

IF 3.9

Experimental gerontology Pub Date : 2024-12-01 DOI:10.1016/j.exger.2024.112642

Zhixing Du , Xiaojing Yan , Yongjian Liu, Yongbin Pei, Jin Zhou, Lei Zhang, Dandan Han, Litao Chen

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引用次数: 0

摘要

目的：本研究探讨了精准健康管理与双能 X 射线吸收测定（DXA）疗法相结合对老年骨质疏松症患者骨生物标志物的影响：本研究探讨了精准健康管理结合双能 X 射线吸收测定（DXA）疗法对老年骨质疏松症患者骨生物标志物的影响。方法：选取我院 2020 年 5 月至 2021 年 11 月期间确诊的 236 例老年骨质疏松症患者。患者被随机分配到观察组（n = 118）或对照组（n = 118），前者在接受 DXA 治疗的同时接受精准健康管理，后者则接受标准治疗。对两组患者的临床数据进行比较。使用 Western 印迹法分析骨形成标志物（BSAP、OC）和骨吸收标志物（CTX、DPD、TRAP）的蛋白质水平。在基线、12 个月和 24 个月时使用 DXA 测量骨矿物质密度（BMD）。在相同的时间间隔内，使用视觉模拟量表（VAS）对疼痛程度进行评估。干预前后分别使用相应的量表对骨质疏松症知识和自我管理信心进行评估：结果：各组的基线特征无明显差异（P>0.05）。与对照组相比，观察组的 BSAP 表达量减少，OC 和 OC 蛋白表达量增加（P 0.05）。然而，在 12 个月和 24 个月的过程中，观察组的 BMD 显著增加（P 结论：观察组的 BMD 增加与对照组相比没有明显差异（P > 0.05）：精准健康管理与 DXA 治疗相结合，通过增强骨生物标志物、促进骨生长和预防骨流失，对老年骨质疏松症患者产生积极影响。这种方法可增加骨密度，降低骨折风险，改善疼痛管理，增强与骨质疏松症相关的知识和自我管理能力。

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Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients

Objective

This study investigates the effects of precision health management combined with dual-energy X-ray absorptiometry (DXA) therapy on bone biomarkers in elderly osteoporotic patients.

Methods

236 elderly patients diagnosed with osteoporosis between May 2020 and November 2021 were enrolled from our hospital. Patients were randomly allocated to either the observation group (n = 118), receiving precision health management alongside DXA therapy, or the control group (n = 118), receiving standard treatment. Clinical data were compared between the two groups. Protein levels of bone formation markers (BSAP, OC) and bone resorption markers (CTX, DPD, TRAP) were analyzed using Western blotting. Bone mineral density (BMD) was measured using DXA at baseline, 12 months, and 24 months. Pain levels were assessed using the Visual Analog Scale (VAS) at the same intervals. Osteoporosis knowledge and self-management confidence were evaluated using respective scales before and after intervention.

Results

Baseline characteristics did not significantly differ between groups (P > 0.05). The observation group exhibited decreased BSAP and increased OC and OC protein expressions compared to the control group (P < 0.05). CTX, DPD, and TRAP protein levels were significantly lower in the observation group (P < 0.05). Prior to the intervention, there were no significant variations observed in BMD, as well as VAS, knowledge, and self-efficacy scores between the two groups (P > 0.05). However, over the course of 12 and 24 months, the observation group exhibited significant increases in BMD (P < 0.05). VAS scores were notably lower in the observation group during both follow-up assessments (P < 0.05). Furthermore, knowledge scores were higher in the observation group at 12 and 24 months (P < 0.05), while self-efficacy scores showed significant improvement in the observation group at both follow-up intervals (P < 0.05).

Conclusion

Precision health management combined with DXA therapy positively impacts elderly osteoporotic patients by enhancing bone biomarkers, promoting bone growth, and preventing bone loss. This approach leads to increased BMD, reduced fracture risk, improved pain management, and enhanced knowledge and self-management abilities related to osteoporosis.

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来源期刊

Experimental gerontology Ageing, Biochemistry, Geriatrics and Gerontology

CiteScore

6.70

自引率

0.00%

发文量

审稿时长

66 days