P16阴性口咽鳞癌中REV7表达的意义

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-11-28 DOI:10.1002/hed.28015

Kaho Momiyama, Shohei Tsutsumi, Yasutaka Sakurai, Sachiyo Mogi, Shunsuke Miyamoto, Yoshiki Murakumo, Taku Yamashita

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引用次数: 0

摘要

背景：REV7是一种多功能蛋白，参与多种生物过程，包括DNA损伤反应。REV7在人类癌细胞中的表达影响着癌细胞对DNA损伤因子的敏感性，据报道，REV7的高表达水平与许多癌症的不良预后有关。然而，REV7在人乳头瘤病毒16阴性口咽鳞状细胞癌（OPSCC）中表达的意义仍不清楚：通过免疫组化分析评估了79例HPV16阴性口咽鳞癌患者的REV7表达情况。我们评估了抑制REV7表达对HPV16阴性咽部SCC细胞系FaDu的增殖和顺铂敏感性的影响：结果：在p16阴性OPSCC患者中，高REV7表达组的总生存期在Cox回归分析中明显短于低REV7表达组（P = 0.03）。此外，REV7缺陷的FaDu细胞在体外显示出细胞生长受抑制，对顺铂的敏感性增强：REV7的表达与HPV16阴性OPSCC的不良预后有关。

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Significance of REV7 Expression in p16-Negative Oropharyngeal Squamous Cell Carcinoma.

Background: REV7 is a multifunctional protein involved in various biological processes, including DNA damage response. REV7 expression in human cancer cells influences sensitivity to DNA-damaging agents, and its high expression level is reportedly associated with a poor prognosis in many carcinomas. However, the significance of REV7 expression in human papillomavirus 16-negative oropharyngeal squamous cell carcinoma (OPSCC) remains unclear.

Methods: REV7 expression was assessed by immunohistochemical analysis in 79 patients with HPV16-negative OPSCC. We evaluated the effects of inhibiting REV7 expression on the proliferation and cisplatin sensitivity of FaDu, an HPV16-negative pharyngeal SCC cell line.

Results: In patients with p16-negative OPSCC, the high-REV7-expression group experienced significantly shorter overall survival than the low-REV7-expression group (p = 0.03) in the Cox regression analysis. Furthermore, REV7-deficient FaDu cells showed suppressed cell growth and enhanced sensitivity to cisplatin in vitro.

Conclusions: REV7 expression is associated with a poor prognosis in HPV16-negative OPSCC.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.