Victoria Wang, Jessica A Walsh, JoAnn Zell, Lauren E Verrilli, Joseph M Letourneau, Erica B Johnstone, Kristina Allen-Brady, Corrine K Welt
{"title":"原发性卵巢功能不全妇女的自身免疫性疾病增加","authors":"Victoria Wang, Jessica A Walsh, JoAnn Zell, Lauren E Verrilli, Joseph M Letourneau, Erica B Johnstone, Kristina Allen-Brady, Corrine K Welt","doi":"10.1210/clinem/dgae828","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Autoimmune disease is common in women with primary ovarian insufficiency (POI), and the genetic etiology of autoimmune disease suggests that it could be hereditary in families of women with POI.</p><p><strong>Objective: </strong>We hypothesized that a subset of women with POI and their family members would have an increased risk for autoimmune disorders.</p><p><strong>Design: </strong>Population-based study using electronic health records from 1995 to 2022.</p><p><strong>Setting: </strong>Two major Utah healthcare systems serving 85% of the state.</p><p><strong>Subjects: </strong>Women with POI (n = 610) were identified using International Classification of Diseases (ICD) codes and charts were reviewed for accuracy. First-, second-, and third-degree relatives were identified using genealogy data in the Utah Population Database.</p><p><strong>Intervention: </strong>Autoimmune diagnoses were identified using ICD codes.</p><p><strong>Main outcome measures: </strong>The relative risk of autoimmune disease in women with POI and relatives was estimated by comparison to population rates.</p><p><strong>Results: </strong>At least 1 autoimmune disease was identified in 25% of women with POI. The relative risk of autoimmune hypothyroidism (odds ratio [95% confidence interval] 6.88 [5.71, 8.22]; P < .001), adrenal insufficiency (4.72 [1.73, 10.28]; P = .0020), type 1 diabetes (4.13 [2.14, 7.22]; P = 5.25X10-5), rheumatoid arthritis (5.66 [3.10, 9.50]; P = 3.70X10-7), vitiligo (15.33 [6.16, 31.58]; P = 5.25X10-7), celiac disease (7.58 [3.47, 14.39]; P = 4.47X10-6), psoriasis (3.90 [2.01, 6.81]; P = 9.04X10-5) and systemic lupus erythematosus (4.43 [1.63, 9.64]; P = .0027) were increased in women with POI compared to population rates. There was no increased risk of autoimmune disease in family members.</p><p><strong>Conclusion: </strong>Data confirm increased autoimmune disease in women with POI. The increased risk is largely related to autoimmune polyglandular syndrome types 1 through 4 and autoimmune hypothyroidism. The absence of risk in family members may result from differences in environmental influences or hormone milieu.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"e2614-e2620"},"PeriodicalIF":5.0000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261096/pdf/","citationCount":"0","resultStr":"{\"title\":\"Autoimmune Disease is Increased in Women With Primary Ovarian Insufficiency.\",\"authors\":\"Victoria Wang, Jessica A Walsh, JoAnn Zell, Lauren E Verrilli, Joseph M Letourneau, Erica B Johnstone, Kristina Allen-Brady, Corrine K Welt\",\"doi\":\"10.1210/clinem/dgae828\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Autoimmune disease is common in women with primary ovarian insufficiency (POI), and the genetic etiology of autoimmune disease suggests that it could be hereditary in families of women with POI.</p><p><strong>Objective: </strong>We hypothesized that a subset of women with POI and their family members would have an increased risk for autoimmune disorders.</p><p><strong>Design: </strong>Population-based study using electronic health records from 1995 to 2022.</p><p><strong>Setting: </strong>Two major Utah healthcare systems serving 85% of the state.</p><p><strong>Subjects: </strong>Women with POI (n = 610) were identified using International Classification of Diseases (ICD) codes and charts were reviewed for accuracy. First-, second-, and third-degree relatives were identified using genealogy data in the Utah Population Database.</p><p><strong>Intervention: </strong>Autoimmune diagnoses were identified using ICD codes.</p><p><strong>Main outcome measures: </strong>The relative risk of autoimmune disease in women with POI and relatives was estimated by comparison to population rates.</p><p><strong>Results: </strong>At least 1 autoimmune disease was identified in 25% of women with POI. The relative risk of autoimmune hypothyroidism (odds ratio [95% confidence interval] 6.88 [5.71, 8.22]; P < .001), adrenal insufficiency (4.72 [1.73, 10.28]; P = .0020), type 1 diabetes (4.13 [2.14, 7.22]; P = 5.25X10-5), rheumatoid arthritis (5.66 [3.10, 9.50]; P = 3.70X10-7), vitiligo (15.33 [6.16, 31.58]; P = 5.25X10-7), celiac disease (7.58 [3.47, 14.39]; P = 4.47X10-6), psoriasis (3.90 [2.01, 6.81]; P = 9.04X10-5) and systemic lupus erythematosus (4.43 [1.63, 9.64]; P = .0027) were increased in women with POI compared to population rates. There was no increased risk of autoimmune disease in family members.</p><p><strong>Conclusion: </strong>Data confirm increased autoimmune disease in women with POI. The increased risk is largely related to autoimmune polyglandular syndrome types 1 through 4 and autoimmune hypothyroidism. The absence of risk in family members may result from differences in environmental influences or hormone milieu.</p>\",\"PeriodicalId\":50238,\"journal\":{\"name\":\"Journal of Clinical Endocrinology & Metabolism\",\"volume\":\" \",\"pages\":\"e2614-e2620\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261096/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Endocrinology & Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1210/clinem/dgae828\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Endocrinology & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/clinem/dgae828","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
背景：自身免疫性疾病是原发性卵巢功能不全（POI）妇女的常见病，而自身免疫性疾病的遗传学病因表明，在原发性卵巢功能不全妇女的家族中，这种疾病可能具有遗传性：我们假设，部分原发性卵巢功能不全妇女及其家庭成员患自身免疫性疾病的风险会增加：设计：基于人群的研究，使用 1995-2022 年间的电子健康记录：环境：犹他州两大医疗保健系统，服务于该州85%的地区：使用 ICD 编码识别患有 POI 的女性（n=610），并审查病历的准确性。通过犹他州人口数据库中的家谱数据确定一级、二级和三级亲属：干预措施：使用 ICD 代码确定自身免疫性疾病诊断：主要结果测量：通过与人口发病率进行比较，估计患有 POI 的妇女及其亲属患自身免疫性疾病的相对风险：结果：25%的 POI 女性患者至少患有一种自身免疫性疾病。自身免疫性甲状腺功能减退症的相对风险（OR [95%CI] 6.88 [5.71, 8.22]；p结论：数据证实了自身免疫性疾病的增加：数据证实，患有 POI 的妇女患自身免疫性疾病的风险增加。风险增加主要与自身免疫性多腺综合征 1 至 4 型和自身免疫性甲状腺功能减退症有关。家族成员没有患病风险可能是由于环境影响或激素环境的差异造成的。
Autoimmune Disease is Increased in Women With Primary Ovarian Insufficiency.
Context: Autoimmune disease is common in women with primary ovarian insufficiency (POI), and the genetic etiology of autoimmune disease suggests that it could be hereditary in families of women with POI.
Objective: We hypothesized that a subset of women with POI and their family members would have an increased risk for autoimmune disorders.
Design: Population-based study using electronic health records from 1995 to 2022.
Setting: Two major Utah healthcare systems serving 85% of the state.
Subjects: Women with POI (n = 610) were identified using International Classification of Diseases (ICD) codes and charts were reviewed for accuracy. First-, second-, and third-degree relatives were identified using genealogy data in the Utah Population Database.
Intervention: Autoimmune diagnoses were identified using ICD codes.
Main outcome measures: The relative risk of autoimmune disease in women with POI and relatives was estimated by comparison to population rates.
Results: At least 1 autoimmune disease was identified in 25% of women with POI. The relative risk of autoimmune hypothyroidism (odds ratio [95% confidence interval] 6.88 [5.71, 8.22]; P < .001), adrenal insufficiency (4.72 [1.73, 10.28]; P = .0020), type 1 diabetes (4.13 [2.14, 7.22]; P = 5.25X10-5), rheumatoid arthritis (5.66 [3.10, 9.50]; P = 3.70X10-7), vitiligo (15.33 [6.16, 31.58]; P = 5.25X10-7), celiac disease (7.58 [3.47, 14.39]; P = 4.47X10-6), psoriasis (3.90 [2.01, 6.81]; P = 9.04X10-5) and systemic lupus erythematosus (4.43 [1.63, 9.64]; P = .0027) were increased in women with POI compared to population rates. There was no increased risk of autoimmune disease in family members.
Conclusion: Data confirm increased autoimmune disease in women with POI. The increased risk is largely related to autoimmune polyglandular syndrome types 1 through 4 and autoimmune hypothyroidism. The absence of risk in family members may result from differences in environmental influences or hormone milieu.
期刊介绍：
The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
