残余胆固醇在血管生成素样 8 与全因、心血管疾病和癌症死亡之间的中介作用：中国心脏代谢疾病和癌症队列（4C）研究。

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2025-03-01 Epub Date: 2024-11-27 DOI:10.1007/s12020-024-04115-5

Peiqiong Luo, Danpei Li, Yaming Guo, Xiaoyu Meng, Ranran Kan, Limeng Pan, Yuxi Xiang, Beibei Mao, Yi He, Siyi Wang, Yan Yang, Zhelong Liu, Junhui Xie, Benping Zhang, Wentao He, Shuhong Hu, Xinrong Zhou, Xuefeng Yu

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引用次数: 0

摘要

目的：研究残余胆固醇（RC）在血管生成素样8（ANGPTL8）与全因、心血管疾病（CVD）和癌症死亡风险之间的潜在中介效应：这项前瞻性观察研究纳入了 3278 名中国人。结果：在长达5年的随访中，ANGPTL8与心血管疾病（CVD）和癌症死亡之间的关系中，RC的中介效应明显：在长达5年的随访中，共记录了265例死亡（8.08%）。ANGPTL8 和 RC 水平的升高与全因、心血管疾病和癌症死亡风险的升高有关。在中国普通人群中，RC水平≥33 mg/dL可识别出死亡风险较高的个体，而不受低密度脂蛋白胆固醇（LDL-C）水平的影响。此外，RC 对 ANGPTL8 水平升高与全因死亡、心血管疾病死亡和癌症死亡风险升高之间的关系有明显的中介作用（中介效应比例分别为 13.10%、9.22% 和 6.07%，均为 p）：循环中ANGPTL8和RC水平的升高都是全因、心血管疾病和癌症死亡的风险因素，而RC在一定程度上介导了ANGPTL8与死亡风险之间的关联。

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The mediating role of remnant cholesterol in the associations of Angiopoietin-like 8 with all-cause, CVD, and cancer death: the China Cardiometabolic Disease and Cancer Cohort (4C) study.

Purpose: To investigate the potential mediating effect of remnant cholesterol (RC) in the associations between angiopoietin-like 8 (ANGPTL8) and the risk of all-cause, cardiovascular disease (CVD), and cancer death.

Methods: This prospective observational study included 3278 individuals from China. Binary logistic regression and mediation analyses were conducted to investigate the mediating effect of RC in the associations between ANGPTL8 and all-cause, CVD, and cancer death.

Results: During up to 5-year follow-up, a total of 265 deaths (8.08%) were documented. Both increased levels of ANGPTL8 and RC were associated with a higher risk of death for all-cause, CVD, and cancer risk. The level of RC ≥ 33 mg/dL could identify individuals at a higher risk of death independent of low-density lipoprotein cholesterol (LDL-C) levels in Chinese general populations. Furthermore, RC significantly mediated the relationship between increased ANGPTL8 levels and higher risk of all-cause, CVD, and cancer death (proportion of mediation effect: 13.10%, 9.22%, and 6.07%, respectively, all p < 0.05).

Conclusion: Both increased circulating levels of ANGPTL8 and RC are the risk factors for all-cause, CVD, and cancer death and RC partially mediates the association between ANGPTL8 and death risk.

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.