[恶性间皮瘤患者 BAP1 蛋白丢失的预后价值]。

Q3 Medicine
Y Q Chen, Z B Gao, W Shen, S B Ying, X L He, X Zhang, Z Q Jiang, J L Lou
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引用次数: 0

摘要

目的探讨BRCA1相关蛋白1(BAP1)在恶性间皮瘤(MM)患者中表达缺失的预后价值。方法:选取浙江省1998年1月至2017年12月的82例MM患者,通过免疫组化分析检测BAP1蛋白的表达。采用 Kaplan-Meier 法绘制生存曲线,采用多变量 Cox 比例风险模型分析影响生存率的因素。结果82例MM患者中,女性61例(74.4%),年龄(57±11)岁。39例患者(47.6%)BAP1蛋白表达缺乏。生存率与 BAP1 蛋白表达缺失和年龄相关(χ(2)=5.27,5.66,P=0.022,0.017)。亚组分析显示,BAP1蛋白表达缺失与MM患者较好的预后相关,PHR=3.75,95%CI:2.23-6.30,PHR=1.66,95%CI:1.01-2.72,P=0.049)是MM患者生存的危险因素。结论BAP1蛋白表达缺失可能是MM患者的一个独立预后因素,它与较长的生存期相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The prognostic value of BAP1 protein loss in patients with malignant mesothelioma].

Objective: To explore the prognostic value of BRCA1-associated protein 1 (BAP1) expression loss in patients with malignant mesothelioma (MM) . Methods: A total of 82 MM patients from January 1998 to December 2017 in Zhejiang Province were selected to detect the expression of BAP1 protein by immunohistochemical analysis. Kaplan-Meier method was used to draw the survival curve, and multivariate Cox proportional risk model was used to analyze the factors affecting the survival rate. Results: Among 82 MM patients, 61 (74.4%) were female, aged (57±11) years. BAP1 protein expression was deficient in 39 patients (47.6%). The survival rate was correlated with the loss of BAP1 protein expression and age (χ(2)=5.27, 5.66, P=0.022, 0.017). Subgroup analysis showed that loss of BAP1 protein expression was associated with better prognosis in MM patients <57 years of age, female, pleural MM, epithelial MM, and treated with drugs or surgery (P<0.05). Multivariate model results showed that positive expression of BAP1 protein (HR=3.75, 95%CI: 2.23-6.30, P<0.001) and age ≥57 years (HR=1.66, 95% CI: 1.01-2.72, P=0.049) were risk factors for survival in patients with MM. Conclusion: Loss of BAP1 protein expression may be an independent prognostic factor in patients with MM, which is associated with longer survival.

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来源期刊
中华劳动卫生职业病杂志
中华劳动卫生职业病杂志 Medicine-Medicine (all)
CiteScore
1.00
自引率
0.00%
发文量
9764
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