Chaochen Yue, Ya Zhang, Juan Xue, Tian Lu, Lei Li, Yanjie Wang, Rui Zhou, Di Gao, Huifang Chai
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Qualitative analysis of chemical constituents and study on the biological activity of Polygonum perfoliatum L.
The chemical constituents of Polygonum perfoliatum L. were qualitatively analysed by UPLC-MS/MS, and the biological activity of its ethanol extract was determined. 94 chemical constituents were identified, including 32 flavonoids, 5 phenylpropanoids, 6 phenols, 6 alkaloids, 13 fatty acyls, 6 organic acids, 12 amino acids and polypeptides, and 14 other classes. The biological activity showed that the antioxidant capacity of the extract increased with the increase in concentration. The inhibitory activity against α-glucosidase IC50 = 1.643 μg/mL; at the concentration of 1 mg/mL, the inhibition rate of MV4-11 and SW480 cells reached more than 90%, and the IC50values were 237.5 μg/mL and 157.6 μg/mL, respectively. The study laid a sure foundation for elucidating the chemical composition and pharmacodynamic basis of Polygonum perfoliatum L.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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