来自 Picralima nitida 的抗疟和抗锥虫病单萜吲哚生物碱。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-11-28 DOI:10.1080/14786419.2024.2434710

Michael Konney Laryea, Kofi Mensah Wonder Abotsi, Eric Woode, Rita Akosua Dickson, Lauren Webster, Edmund Ekuadzi

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引用次数: 0

摘要

八种单萜吲哚生物碱（1-8），包括一种新的皮卡林型生物碱，2-羟基阿枯米林（4）和七种已知化合物：从 Picralima nitida 的种子中分离出了 akuammigine (1)、akuammine (2)、akuammidine (3)、akuammiline (5a)、akuammiline N-oxide (5b)、akuammiline (6)、rhazimol (7) 和 alstonine (8)。通过分析其 MS 和 NMR 光谱数据，对其结构进行了阐明。化合物 1-7 的抗疟效果一般。化合物 8 显示出明显的效果，pXC50 为 6.3。化合物 1 和 7 具有明显的杀锥虫作用，pXC50 分别为 5.1 和 5.4。

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Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from Picralima nitida.

Eight monoterpene indole alkaloids (1-8), including one new picraline-type alkaloid, 2-hydroxyakuammiline (4) and seven known compounds: akuammigine (1), akuammine (2), akuammidine (3), akuammiline (5a), akuammiline N-oxide (5b), akuammiline (6), rhazimol (7), and alstonine (8) were isolated from the seeds of Picralima nitida. Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds 1-7 were moderate. Compound 8 showed significant effects with pXC50 of 6.3. Compounds 1 and 7 showed significant trypanocidal effects with pXC50's of 5.1 and 5.4 respectively.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.