不吃早餐对食道健康的影响：孟德尔随机研究。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2024-11-26 DOI:10.1016/j.clnesp.2024.11.028

Jiaming Lei , Ling Wu

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引用次数: 0

摘要

背景与目的：以往的研究表明，除了进食的食物种类外，饮食习惯也与食道疾病的风险有关。一些研究表明，不吃早餐可能与食管肿瘤和胃食管反流病有关。然而，不吃早餐是否与食道疾病有因果关系仍不清楚。为解决这一问题，本研究旨在采用双样本亡羊补牢随机化（MR）方法，调查不吃早餐与食管疾病之间的潜在因果关系：我们从全基因组关联研究（GWAS）中获得了有关不吃早餐的数据，这些数据来自英国生物库（UK Biobank），涉及 193 860 人。食管疾病的汇总统计数据来自 IEU 开放式 GWAS 项目。在这个双样本磁共振分析中，采用了反方差加权法，并辅以加权中位数法、简单模式法和加权模式法：结果表明，不吃早餐与食管癌之间存在明显的因果关系（几率比（OR）：5.992，95% 置信度：0.01）：5.992，95% 置信区间（CI）：1.606-22.350，p=0.008）、巴雷特食管（OR：4.041，95% CI：1.837-8.889，pConclusion）之间存在明显的因果关系：我们的研究为不吃早餐与食道疾病之间的联系提供了证据。不吃早餐可能是食管癌、巴雷特食管、胃食管反流病和食管静脉曲张的潜在危险因素。对于容易罹患这些食道疾病的高危人群来说，强调定时吃早餐的重要性和保持一贯的饮食习惯对食道健康至关重要。

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Impact of breakfast skipping on esophageal health: A mendelian randomization study

Background & aims

Previous studies have indicated that, in addition to the types of food consumed, eating habits are also associated with the risk of esophageal diseases. Some studies have suggested a possible link between breakfast skipping and esophageal tumors as well as gastroesophageal reflux disease. However, it remains unclear whether breakfast skipping has a causal relationship with esophageal diseases. To address this issue, this study aimed to investigate the potential causal relationship between breakfast skipping and esophageal diseases using a two-sample mendelian randomization (MR) approach.

Methods

We obtained data from genome-wide association studies (GWAS) involving 193,860 individuals from the UK Biobank on breakfast skipping. The summary statistics for the esophageal diseases were derived from the IEU open GWAS project. In this two-sample MR analysis, inverse variance weighted was used, supplemented with weighted median, simple mode and weighted mode methods.

Results

The results revealed significant causal relationships between breakfast skipping and esophageal cancer (odds ratio (OR): 5.992, 95 % confidence interval (CI): 1.606–22.350, p = 0.008), Barrett's esophagus (OR: 4.041, 95 % CI: 1.837–8.889, p < 0.001), gastroesophageal reflux disease (OR: 2.463, 95 % CI: 1.995–3.041, p < 0.001), and esophageal varices (OR: 4.454, 95 % CI: 1.785–11.112, p = 0.001). All of the supplementary methods supported the findings.

Conclusion

Our research provides evidence for the association between breakfast skipping and esophageal diseases. Breakfast skipping could be a potential risk factor for esophageal cancer, Barrett's esophagus, gastroesophageal reflux disease and esophageal varices. For high-risk groups prone to these esophageal diseases, emphasizing the importance of regular breakfast and maintaining consistent dietary habits is crucial for esophageal health.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.