对比敏感度、OCT 特征与中晚期老年性黄斑变性进展之间的关系

IF 4.1 1区 医学 Q1 OPHTHALMOLOGY
Cade Bennett, Francesco Romano, Filippos Vingopoulos, Mauricio Garcia, Xinyi Ding, Augustine Bannerman, Ioanna Ploumi, Dimitrios Ntentakis, Isabella Stettler, Katherine Overbey, Grace Baldwin, Romy Bejjani, Itika Garg, Jocelyn Rodriguez, Inês Laìns, Leo A Kim, Demetrios Vavvas, Deeba Husain, Joan W Miller, John B Miller
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引用次数: 0

摘要

目的:建立中度年龄相关性黄斑变性(iAMD)的结构、功能和临床结果之间的关联仍是一项尚未满足的需求。本研究旨在:(1)横向研究光学相干断层扫描(OCT)生物标志物与定量对比敏感度功能(qCSF)测量的对比敏感度(CS)之间的关系;(2)纵向评估它们与中老年相关性黄斑变性进展到疾病晚期的关系:设计:横断面和队列研究:我们的研究在马萨诸塞州眼耳科医院(波士顿,马萨诸塞州,美国)进行,研究对象包括:(1)基线诊断为 iAMD;(2)当天进行 OCT 和 qCSF 测试;(3)视力(VA)≥20/200 Snellen;(4)随访 24 个月以上。两名独立的评分员对黄斑 OCT 扫描的各种生物标志物进行了审查,并测量了核外层(ONL)厚度和视网膜色素上皮(RPE)体积。湿性老年性黄斑病变(AMD)或地理萎缩(GA)的进展通过成像研究得到确认。广义线性混合效应模型评估了qCSF和OCT生物标志物之间的关联,而Cox回归模型评估了它们与晚期AMD进展的关联:我们纳入了 134 名患者的 205 只 iAMD 眼睛(年龄:73 [69-78] 岁;63% 为女性)。在 6-12 cpd 时,中央子场中较高的 RPE 体积和较多的视网膜内高反射灶 (iHRF) 与 AULCSF、CA 和 CS 的降低有关(pConclusions:我们的研究揭示了 iAMD 中 OCT 生物标志物与 qCSF 测量的 CS 之间的重要结构-功能关系。这些发现凸显了 AMD 改变对 CS 功能的影响,并为研究和临床环境中的患者分层和预后提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations Between Contrast Sensitivity, Optical Coherence Tomography Features and Progression From Intermediate to Late Age-related Macular Degeneration.

Purpose: Establishing associations between structure, function, and clinical outcomes in intermediate age-related macular degeneration (iAMD) remains an unmet need. This study aims to (1) cross-sectionally investigate the relationships between optical coherence tomography (OCT) biomarkers and quantitative contrast sensitivity function (qCSF)-measured contrast sensitivity (CS), and (2) longitudinally assess their relationship with progression from iAMD to late stages of the disease.

Design: Cross-sectional and cohort study.

Methods: Our study was conducted at Massachusetts Eye and Ear (Boston, MA, USA) and included eyes with (1) baseline diagnosis of iAMD, (2) same-day OCT and qCSF test, (3) visual acuity ≥20/200 Snellen, and (4) 24+ months of follow-up. qCSF metrics included the area under the logCSF curve, contrast acuity, and CS thresholds at 1- to 18-cycle-per-degree (cpd). Two independent graders reviewed macular OCT scans for various biomarkers, and outer nuclear layer (ONL) thickness and retinal pigment epithelium (RPE) volume were measured. Progression to wet AMD or geographic atrophy (GA) was confirmed using imaging studies. Generalized linear mixed-effects models assessed associations between qCSF and OCT biomarkers, while Cox regression models evaluated their association with progression to late AMD.

Results: We included 205 iAMD eyes from 134 patients (age: 73 [69-78] years; 63% female). Higher RPE volume in the central subfield and a greater number of intraretinal hyperreflective foci were associated with reduced area under the logCSF curve, contrast acuity, and CS at 6 to 12 cpd (P < .05). ONL thinning in the inner ring and a greater number of intraretinal hyperreflective foci were associated with reduced CS at 1 and 3 cpd (P < .05). During follow-up, 35 eyes developed wet AMD (17%) and 53 progressed to GA (26%). subretinal drusenoid deposit, ONL thinning in the inner ring, and reduced CS at 1.5 cpd were associated with wet AMD (P < .05). Higher RPE volume in the inner ring, hyporeflective drusen cores, subretinal drusenoid deposit, higher HRF count, and reduced CS at 1 cpd were associated with GA (P < .05).

Conclusions: Our study reveals significant structure-function relationships between OCT biomarkers and qCSF-measured CS in iAMD. These findings highlight the impact of AMD alterations on CS function and offer valuable insights for patient stratification and prognostication in research and clinical settings.

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来源期刊
CiteScore
9.20
自引率
7.10%
发文量
406
审稿时长
36 days
期刊介绍: The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.
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