与青春期或妊娠期相比,哺乳期的高脂肪饮食会导致成年后代的心脏代谢和自律神经功能紊乱。

IF 2.7 4区 医学 Q3 NEUROSCIENCES
Annie Araújo Alves dos Santos , Rosana Torrezan , Willian do Nascimento de Souza Rodrigues, Maiara Vanusa Guedes Ribeiro, Anna Rebeka Oliveira Ferreira, Maria Natália Chimirri Peres, Lucas Paulo Jacinto Saavedra, Scarlett Rodrigues Raposo, Douglas Lopes Almeida, Ananda Malta , Paulo Cezar de Freitas Mathias
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引用次数: 0

摘要

健康与疾病的发展起源(DOHaD)概念已经确立了三十年。许多研究表明,除妊娠期外,其他可塑性阶段(主要是孕前、哺乳期和婴儿期至青春期)对环境变化(包括营养状况)也很敏感,这些变化可为日后的健康或疾病埋下伏笔。本研究比较了妊娠期、哺乳期和青春期对高脂饮食(HFD)干预的易感性,以编程大鼠成年后的自律神经系统失衡和心脏代谢功能障碍。研究了四组大鼠:妊娠期接触高脂饮食(35% 脂肪)或标准饲料(4.5% 脂肪)的母鼠的后代(分别为 GEST 组和 CONT 组)、哺乳期接触高脂饮食的母鼠的后代(LAC)以及接触高脂饮食的青春期大鼠(ADOL)。妊娠期母鼠的体重较高,但哺乳期母鼠的食物能量摄入量最高,脂肪含量也较高。与其他组相比,LAC 组大鼠的体重增加、食物能量摄入、体脂、葡萄糖不耐受和血压均有所增加。LAC 组还表现出副交感神经活动增加。相反,与其他组相比,LAC 组交感神经活性降低。ADOL 组表现出大部分类似的反应,但幅度较小。这表明,哺乳期对高密度脂蛋白胆固醇(HFD)最敏感,会导致成年后的心血管代谢功能障碍,而且早期营养过剩可能会通过改变自律神经系统的平衡来影响神经连接。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

High-fat diet during lactation, as opposed to during adolescence or gestation, programs cardiometabolic and autonomic dysfunctions in adult offspring

High-fat diet during lactation, as opposed to during adolescence or gestation, programs cardiometabolic and autonomic dysfunctions in adult offspring
The Developmental Origins of Health and Disease (DOHaD) concept has been established for three decades. Many studies have shown that, besides pregnancy, other plastic phases (mainly preconception, lactation, and infancy–adolescence) are also sensitive to environmental changes, including nutritional conditions, that can program health or disease later in life. This study compared the susceptibility of the gestation, lactation and adolescence to a high-fat diet (HFD) intervention to program rats into autonomic nervous system imbalance and cardiometabolic dysfunction in adulthood. Four groups of rats were studied: offspring from mothers exposed to a HFD (35% fat) or a standard chow diet (4.5% fat) during gestation (GEST and CONT groups, respectively), offspring from mothers exposed to the HFD during lactation (LAC), and adolescent rats exposed to the HFD (ADOL). Mothers treated during pregnancy exhibited a higher body mass, but nursing mothers presented the highest food energy intake and higher adiposity. Compared to the other groups, the LAC rats showed increased body mass gain, food energy intake, body fat, glucose intolerance and blood pressure. LAC group also showed increased parasympathetic activity. In contrast, LAC sympathetic nerve activity decreased compared with the other groups. The ADOL group exhibited mostly similar responses but of a smaller magnitude. This suggests that the lactation phase is the most sensitive to HFD programming for cardiometabolic dysfunction in adulthood and that early overnutrition may affect neural connections by altering the autonomic nervous system balance.
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来源期刊
Brain Research
Brain Research 医学-神经科学
CiteScore
5.90
自引率
3.40%
发文量
268
审稿时长
47 days
期刊介绍: An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.
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