多功能粘合水凝胶:从设计到生物医学应用。

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Shaoxin Tang, Keru Feng, Rui Yang, Yang Cheng, Meiyue Chen, Hui Zhang, Nianyuan Shi, Zhao Wei, Hui Ren, Yufei Ma
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引用次数: 0

摘要

粘附性水凝胶具有与细胞外基质相似的结构特性、优异的生物相容性、可控降解和可调机械特性,在组织工程、生物传感器和药物输送系统等生物医学应用领域具有巨大潜力。这些水凝胶在目标基底上表现出显著的粘附性,并可根据特定要求进行合理设计。近几十年来,在众多多功能设计策略的推动下,粘合性水凝胶取得了长足的进步。本综述首先总结了基于化学键的组织粘附性设计策略,包括静态共价键、动态共价键和非共价相互作用。随后,将讨论这些不同的设计策略所赋予的多种功能,包括高拉伸性和韧性、对微环境的响应性、抗冷冻/加热特性、导电性、抗菌活性和止血特性。此外,还回顾了粘合水凝胶在生物医学应用方面的最新进展,重点关注组织修复、药物输送、医疗器械和可穿戴传感器。最后,强调了当前面临的挑战,并讨论了这一快速发展领域的未来趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multifunctional Adhesive Hydrogels: From Design to Biomedical Applications.

Adhesive hydrogels characterized by structural properties similar to the extracellular matrix, excellent biocompatibility, controlled degradation, and tunable mechanical properties have demonstrated significant potential in biomedical applications, including tissue engineering, biosensors, and drug delivery systems. These hydrogels exhibit remarkable adhesion to target substrates and can be rationally engineered to meet specific requirements. In recent decades, adhesive hydrogels have experienced significant advancements driven by the introduction of numerous multifunctional design strategies. This review initially summarizes the chemical bond-based design strategies for tissue adhesion, encompassing static covalent bonds, dynamic covalent bonds, and non-covalent interactions. Subsequently, the multiple functionalities imparted by these diverse design strategies, including highly stretchable and tough performances, responsiveness to microenvironments, anti-freezing/heating properties, conductivity, antibacterial activity, and hemostatic properties are discussed. In addition, recent advances in the biomedical applications of adhesive hydrogels, focusing on tissue repair, drug delivery, medical devices, and wearable sensors are reviewed. Finally, the current challenges are highlighted and future trends in this rapidly evolving field are discussed.

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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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