通过巴比耶型烯丙基加成法锻造 euphordraculoate B 的三环核心框架。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-11-28 DOI:10.1039/d4ob01743a

Lingduan Meng, Jingjing Liu, Zeying Sun, Yangdong Hou, Qingyun Huang, Pingping Tang

{"title":"通过巴比耶型烯丙基加成法锻造 euphordraculoate B 的三环核心框架。","authors":"Lingduan Meng, Jingjing Liu, Zeying Sun, Yangdong Hou, Qingyun Huang, Pingping Tang","doi":"10.1039/d4ob01743a","DOIUrl":null,"url":null,"abstract":"A novel strategy for the synthesis of an advanced intermediate en route to the tigliane derivative euphordraculoate B was described, which led to the successful construction of the 5/5/6 tricyclic core framework as well as the multiple consecutive stereocenters on the skeleton. Key steps of the strategy include a chlorination reaction, an aldol reaction, and a Barbier-type allyl addition.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Forging the tricyclic core framework of euphordraculoate B via a Barbier-type allyl addition.\",\"authors\":\"Lingduan Meng, Jingjing Liu, Zeying Sun, Yangdong Hou, Qingyun Huang, Pingping Tang\",\"doi\":\"10.1039/d4ob01743a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A novel strategy for the synthesis of an advanced intermediate en route to the tigliane derivative euphordraculoate B was described, which led to the successful construction of the 5/5/6 tricyclic core framework as well as the multiple consecutive stereocenters on the skeleton. Key steps of the strategy include a chlorination reaction, an aldol reaction, and a Barbier-type allyl addition.\",\"PeriodicalId\":96,\"journal\":{\"name\":\"Organic & Biomolecular Chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-11-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic & Biomolecular Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d4ob01743a\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01743a","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

本研究介绍了一种合成惕各烷衍生物极草酮酸 B 高级中间体的新策略，该策略成功地构建了 5/5/6 三环核心框架以及骨架上的多个连续立体中心。该策略的关键步骤包括氯化反应、醛醇反应和巴比耶型烯丙基加成反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Forging the tricyclic core framework of euphordraculoate B via a Barbier-type allyl addition.

A novel strategy for the synthesis of an advanced intermediate en route to the tigliane derivative euphordraculoate B was described, which led to the successful construction of the 5/5/6 tricyclic core framework as well as the multiple consecutive stereocenters on the skeleton. Key steps of the strategy include a chlorination reaction, an aldol reaction, and a Barbier-type allyl addition.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： The international home of synthetic, physical and biomolecular organic chemistry.