新生儿未结合高胆红素血症的不同治疗方法:综述文章

IF 3.4 Q2 PHARMACOLOGY & PHARMACY
Amira A. Fouly, Ehab R. Bendas, Yasmin A. Farid, Sarah Sabry, Dina K. Abou El Fadl
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引用次数: 0

摘要

背景新生儿高胆红素血症是一种影响新生儿的常见病,其特点是血清胆红素水平升高。胆红素蓄积可引起神经中毒,导致各种并发症,严重者甚至死亡。这种病症的基本病理生理学主要涉及胆红素合成和排泄之间的不一致。尽管光疗有短期和长期的副作用,但仍被认为是新生儿高胆红素血症的核心治疗方法。交换性输血被认为是光疗失败后的最后手段。有几项研究探讨了使用各种药物替代光疗或作为辅助药物,以缩短光疗所需的时间,从而将不良反应降至最低。本综述总结了新生儿高胆红素血症的病因。本综述总结了新生儿高胆红素血症的病因,并指出新生儿高胆红素血症主要有两种类型:结合型和非结合型高胆红素血症。会议讨论了新生儿高胆红素血症的治疗方案,其中光疗是最普遍、最成功的方案,其次是交换性输血。结论光疗是治疗新生儿高胆红素血症最成功的方法,但其副作用也备受关注。引入硫酸锌和熊去氧胆酸等辅助剂的研究显示,在缩短光疗时间和减少副作用方面取得了可喜的成果。然而,这些研究结果尚无定论,还需要进一步的研究来验证这些辅助剂的安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Different approaches in management of neonatal unconjugated hyperbilirubinemia: a review article

Background

Neonatal hyperbilirubinemia is a prevalent condition that affects newborns, characterized by elevated serum bilirubin levels. The accumulation of bilirubin can cause neurotoxicity, resulting in various complications, and in severe cases, even mortality. The underlying pathophysiology of this condition primarily involves an inconsistency between the synthesis and excretion of bilirubin. Despite the short- and long-term side effects of phototherapy, it is considered a core treatment of neonatal hyperbilirubinemia. Exchange transfusion is considered a last resort in cases where phototherapy fails. Several studies have investigated the use of various agents either to replace phototherapy or to be added as adjuvants to reduce the time required for phototherapy and hence minimize the adverse effects. Some of these studies have demonstrated positive outcomes, indicating their effectiveness, while others have failed to yield any significant differences in treatment duration.

Main text

The present review summarized the etiology of neonatal hyperbilirubinemia. It was demonstrated that neonatal hyperbilirubinemia has mainly two types: Conjugated and unconjugated hyperbilirubinemia. Treatment options for neonatal hyperbilirubinemia were discussed with phototherapy as the most prevalent and successful option followed by exchange transfusion. Side effects of phototherapy were also discussed together with the different approaches introduced to clinical practice to minimize these side effects.

Conclusion

Phototherapy is the most successful treatment of neonatal hyperbilirubinemia, although its side effects are of great concern. Studies introducing adjuvants such as zinc sulfate and ursodeoxycholic acid have demonstrated promising results in reducing the duration of phototherapy and minimizing the side effects. However, these results are inconclusive, and further research is required to validate the safety and efficacy of these adjuvants.

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来源期刊
自引率
0.00%
发文量
44
审稿时长
23 weeks
期刊介绍: Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.
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