[18F]AlF-LNC1007、[18F]FDG 和 [18F]AlF-NOTA-FAPI-04 PET/CT 在乳腺癌诊断中的比较研究：方法探索与分析启示

IF 8.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-11-28 DOI:10.1021/acsami.4c17912

Haiyan Gao, Jie Chen, Zhichuan Yang, Ziyang Zhu, Limeng He, Wei Zhang, Xiaoyuan Chen, Jingjing Zhang

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引用次数: 0

摘要

目的比较[18F]AlF-LNC1007、[18F]FDG和[18F]AlF-NOTA-FAPI-04 PET/CT对乳腺癌的诊断价值。方法：33 名高度怀疑或已确诊但未经治疗的乳腺癌患者被纳入研究，并接受了[18F]AlF-LNC1007（30 例）、[18F]FDG（22 例）和[18F]AlF-NOTA-FAPI-04（8 例）PET/CT 检查。定量测量包括所有病灶和背景组织的 SUVmax 和肿瘤与背景比值 (TBR)。组间诊断效果采用Chi-square检验，组间SUVmax或TBR采用Wilcoxon检验。淋巴结转移的诊断效果采用接收器操作特征（ROC）分析进行评估。结果与[18F]FDG相比，[18F]AlF-LNC1007对淋巴结转移的阳性预测值更高（100% vs 91%，P = 0.0004）（42 vs 46），对骨转移的敏感性更高（100 vs 76%，P = 0.0003）（33 vs 25），但对肝转移的敏感性较低（93 vs 100%，P = 0.001）。除肝转移瘤外，[18F]AlF-LNC1007 PET/CT 在原发肿瘤和其他转移瘤中的 SUVmax 较高，但在 TBR 中无统计学差异。与[18F]AlF-NOTA-FAPI-04 PET/CT 相比，[18F]AlF-LNC1007 在骨转移瘤中的假阳性更少，阳性预测值更高（99 vs 95%，P = 0.0003），但在所有原发和转移病灶中的 SUVmax 更低（P < 0.01）。[18F]AlF-LNC1007和[18F]AlF-NOTA-FAPI-04之间的TBR差异仅在骨转移瘤中有统计学意义（5.97 vs 5.02，P = 0.001）。[18F]AlF-LNC1007和[18F]FDG PET/CT的淋巴结检测效果比较显示，诊断淋巴结转移的SUVmax截断值（2.62 vs 3.90）、敏感性（95.2% vs 66.67）和特异性（100% vs 85.00）均有显著差异（均为P <0.001）。结论[18F]AlF-LNC1007的疗效优于[18F]FDG和[18F]AlF-NOTA-FAPI-04，在原发肿瘤、淋巴结和骨转移灶的摄取率高于[18F]FDG，TBR高于[18F]AlF-NOTA-FAPI-04，尤其是在骨转移灶。[18F]AlF-LNC1007在区分炎性淋巴结和转移性淋巴结方面也表现出很高的特异性。

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Comparative Study of [18F]AlF-LNC1007, [18F]FDG, and [18F]AlF-NOTA-FAPI-04 PET/CT in Breast Cancer Diagnosis: A Methodological Exploration and Analytical Insight

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Comparative Study of [18F]AlF-LNC1007, [18F]FDG, and [18F]AlF-NOTA-FAPI-04 PET/CT in Breast Cancer Diagnosis: A Methodological Exploration and Analytical Insight

Objective: To compare the diagnostic value of [¹⁸F]AlF-LNC1007, [¹⁸F]FDG, and [¹⁸F]AlF-NOTA-FAPI-04 PET/CT in breast cancer. Methods: 33 patients with highly suspected or already diagnosed but untreated breast cancer were enrolled in the study and underwent [¹⁸F]AlF-LNC1007 (30 patients), [¹⁸F]FDG (22 patients), and [¹⁸F]AlF-NOTA-FAPI-04 (8 patients) PET/CT. Quantitative measurements included the SUV_max and tumor-to-background ratio (TBR) for all lesions and background tissues. The Chi-square test was used for intergroup diagnostic efficacy, and the Wilcoxon test was used for intergroup SUV_max or TBR. Diagnostic efficacy for lymph node metastasis was evaluated using receiver operating characteristic (ROC) analysis. Results: Compared to [¹⁸F]FDG, [¹⁸F]AlF-LNC1007 had a higher positive predictive value (100% vs 91%, P = 0.0004) in lymph node metastases (42 vs 46) and higher sensitivity (100 vs 76%, P = 0.0003) in bone metastases (33 vs 25) but lower sensitivity (93 vs 100%, P = 0.001) in liver metastases. Apart from liver metastases, [¹⁸F]AlF-LNC1007 PET/CT had higher SUV_max in primary tumor and other metastases, with no statistical difference in TBR. Compared to [¹⁸F]AlF-NOTA-FAPI-04 PET/CT, [¹⁸F]AlF-LNC1007 had less false-positive and a higher positive predictive value in bone metastases (99 vs 95%, P = 0.0003) but had lower SUV_max(P < 0.01) in all primary and metastases lesions. The TBR difference between [¹⁸F]AlF-LNC1007 and [¹⁸F]AlF-NOTA-FAPI-04 was statistically significant only in bone metastases (5.97 vs 5.02, P = 0.001). The comparison of lymph node detection efficacy between [¹⁸F]AlF-LNC1007 and [¹⁸F]FDG PET/CT showed significant differences in SUV_max cutoff values for diagnosing lymph node metastases (2.62 vs 3.90), sensitivity (95.2% vs 66.67), and specificity (100% vs 85.00) (all P < 0.001). Conclusion: [¹⁸F]AlF-LNC1007 demonstrated superior efficacy compared to [¹⁸F]FDG and [¹⁸F]AlF-NOTA-FAPI-04 and higher uptake than [¹⁸F]FDG in primary tumor, lymph node and bone metastases, and higher TBR than [¹⁸F]AlF-NOTA-FAPI-04, especially in bone metastases. [¹⁸F]AlF-LNC1007 also showed high specificity in differentiating inflammatory and metastatic lymph nodes.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.