用于头颈癌研究的棉尾兔乳头瘤病毒(CRPV)相关动物模型:文献综述》。

IF 3.8 3区 医学 Q2 VIROLOGY
Viruses-Basel Pub Date : 2024-10-31 DOI:10.3390/v16111722
Michael Bette, Robert Mandic
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引用次数: 0

摘要

拥有合适的动物模型对于模拟人类疾病状态以及将实验数据成功转化为临床实践至关重要。在乳头状瘤病毒研究领域,家兔(Oryctolagus cuniculus)作为不可或缺的模型生物体已有近 100 年的历史。首批家兔乳头状瘤病毒的鉴定和特征描述、其致癌潜力和免疫原性,极大地促进了人们对乳头状瘤病毒遗传学和生命周期的总体认识,并推动了疫苗接种等抗病毒策略的发展。由于乳头状瘤病毒具有高度的物种特异性,只有兔乳头状瘤病毒(RPV)可用于兔乳头状瘤肿瘤疾病的动物研究。本文的重点是棉尾兔乳头瘤病毒(CRPV)相关的兔鳞状细胞癌(RSCC)。文章简要介绍了发现和产生实验用 RSCC 肿瘤的历史。本文全面概述了目前基于CRPV相关VX2癌的肿瘤模型,重点介绍了人类头颈部鳞状细胞癌(HNSCC)肿瘤模型,并讨论了这些肿瘤模型在转用于人类HNSCC方面的优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cottontail Rabbit Papillomavirus (CRPV) Related Animal Models for Head and Neck Cancer Research: A Comprehensive Review of the Literature.

Having suitable animal models is crucial to mimic human disease states and for the successful transfer of experimental data into clinical practice. In the field of papillomavirus research, the domestic rabbit (Oryctolagus cuniculus) has served as an indispensable model organism for almost 100 years. The identification and characterization of the first papillomaviruses in rabbits, their carcinogenic potential and their immunogenicity have contributed significantly to the state of knowledge on the genetics and life cycle of papillomaviruses in general, as well as the development of antiviral strategies such as vaccination procedures. Due to the high species specificity of papillomaviruses, only rabbit papillomaviruses (RPVs) can be used for animal studies on papilloma-based tumor diseases in the rabbit. The major focus of this article is on cottontail rabbit papillomavirus (CRPV)-related rabbit squamous cell carcinoma (RSCC). A brief history outlines the discovery and generation of experimentally used RSCC tumors. A comprehensive overview of the current CRPV-associated VX2 carcinoma-based tumor models with a major focus on human head and neck squamous cell carcinoma (HNSCC) tumor models is provided, and their strengths in terms of transferability to human HNSCC are discussed.

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来源期刊
Viruses-Basel
Viruses-Basel VIROLOGY-
CiteScore
7.30
自引率
12.80%
发文量
2445
审稿时长
1 months
期刊介绍: Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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