日本婴儿接种轮状病毒疫苗后立即出现肠套叠的风险明显缺乏。

IF 3.8 3区 医学 Q2 VIROLOGY
Viruses-Basel Pub Date : 2024-11-10 DOI:10.3390/v16111758
Wakako Kikuchi, Atsuko Noguchi, Yoko Sato, Yuuki Konno, Akira Komatsu, Satoru Tandai, Wataru Kikuchi, Shinobu Miura, Hiroshi Fukaya, Tomoaki Ohata, Hiroo Noguchi, Kenichi Matsuno, Hisayuki Tsukahara, Daiki Kondo, Masaki Komatsu, Masamichi Tamura, Hiromi Koizumi, Toyoko Nakagomi, Osamu Nakagomi, Tsutomu Takahashi
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引用次数: 0

摘要

在肠套叠背景发病率相对较低的美国、欧洲、澳大利亚和拉丁美洲,轮状病毒疫苗主要会在接种后 1-7 天产生肠套叠的小风险。在本底率最低的非洲和印度,这种风险是无法检测到的。由于在日本等高背景率国家开展的研究很少,我们研究了在日本秋田县生活的婴儿肠套叠发生的情况,当时疫苗在私人市场上销售。2011 年至 2018 年间,估计有 21677 名婴儿(46%)接种了疫苗,54% 的婴儿没有接种。通过对该县 18 家医院的病历进行回顾性调查,我们发现有 58 名婴儿患有符合布莱顿标准 1 级的肠套叠,其中 28 名接种了疫苗,30 名未接种疫苗。因此,肠套叠发生率为每 10 万婴儿年 123 例(95% 置信区间 [CI]:94-160)。尽管肠套叠发生率很高,但无论是接种单价人轮状病毒疫苗(葛兰素史克)还是五价人-牛重配疫苗(MSD)后 1-7 天,均无婴儿发生肠套叠。据估计,出生后 42 到 245 天内接种过疫苗的婴儿与未接种疫苗的婴儿的发病率比为 0.96(95%CI:0.43-2.1;P = 0.92)。鉴于超过 95% 的婴儿在 15 周岁前接种了第一剂疫苗,因此在高发病率国家,只要在婴儿 2、3 和 4 个月大时按照建议的时间表接种轮状病毒疫苗,就能将肠套叠的相关风险降至最低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Apparent Lack of the Risk of Intussusception Immediately After Rotavirus Vaccination Among Japanese Infants.

Rotavirus vaccines carry a small risk of intussusception mainly 1-7 days after vaccination in the United States of America, Europe, Australia, and Latin America where the background rate of intussusception is relatively low. Such risks are undetectable in Africa and India where the background rate is the lowest. Because few studies were carried out in high-background-rate countries such as Japan, we examined how intussusception occurred in infants living in Akita prefecture, Japan, while the vaccines were sold in the private market. Between 2011 and 2018, an estimated 21,677 infants (46%) were vaccinated and 54% were not. Through a retrospective survey of medical records in 18 hospitals in the prefecture, we identified 58 infants, 28 of whom were vaccinated and 30 of whom were unvaccinated, as having intussusception that met level 1 of the Brighton criteria. Thus, the intussusception rate was 123 per 100,000 infant-years (95% confidence interval [CI]: 94-160). Despite the high rate, none developed intussusception 1-7 days after the first dose of either the monovalent human rotavirus vaccine (GSK) or the pentavalent human-bovine reassortant vaccine (MSD). The incidence rate ratio of vaccinated to unvaccinated infants between 42 and 245 days of life was estimated at 0.96 (95%CI: 0.43-2.1; p = 0.92). Given that over 95% of infants received the first dose before 15 weeks of age, the risk of intussusception associated with the rotavirus vaccines in high-incidence-rate countries can be reduced to a minimum by adhering to the recommended schedule at 2, 3, and 4 months of age.

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来源期刊
Viruses-Basel
Viruses-Basel VIROLOGY-
CiteScore
7.30
自引率
12.80%
发文量
2445
审稿时长
1 months
期刊介绍: Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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