使用磁共振热量计和磁共振超声波成像技术进行经颅磁共振成像引导的组织切片定位。

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-02-01 DOI:10.1016/j.ultrasmedbio.2024.10.010

Dinank Gupta , Tarana P. Kaovasia , Mahmoud Komaiha , Jon-Fredrik Nielsen , Steven P. Allen , Timothy L. Hall , Douglas C. Noll , Zhen Xu

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引用次数: 0

摘要

目的：经颅磁共振成像（MRI）引导的组织切削术已被证实可通过人的头骨治疗体内猪脑的不同位置。为确保将组织切碎术治疗送到预定的目标位置，必须进行精确的治疗前定位。在这项工作中，我们研究了利用磁共振温度测量和磁共振声辐射力成像（MR-ARFI）对穿透人头骨的体外牛脑进行组织切碎术治疗前定位的可行性：方法：使用一个 700 kHz、128 元磁共振兼容组织切削阵列来产生组织切削和音爆声波。对该阵列的电子驱动器进行了改装，使其也能产生低振幅音爆声波，以进行磁共振测温和基于磁共振-ARFI的靶向定位。在 35 兆帕、75 兆帕和 36 兆帕的压力下，对 12 个活体牛脑进行了组织碎裂处理。在处理组织之前，使用磁共振超声波成像和磁共振测温来估计病变位置。最后，将组织切割病灶的位置与磁共振测温法和磁共振-ARFI估计的病灶位置进行比较：结果：MR-热成像仪和MR-ARFI能够使用改进的组织切割阵列驱动器成功地进行组织切割治疗前定位。MR-ARFI和MR-热成像仪沿横向/纵向轴估算的组织切削病灶平均绝对误差分别为2.06/2.95毫米和2.13/2.51毫米。人体头骨的存在降低了病灶区域的压力，但这并不影响两种方法的定位精度，MR-ARFI 和 MR-thermometry 的平均绝对误差分别为 1.10/2.91 毫米和 1.29/2.91 毫米：本研究表明，经颅组织电切术治疗前靶向定位在 MR-thermometry 和 MR-ARFI 下是可行的。

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Transcranial MRI-guided Histotripsy Targeting Using MR-thermometry and MR-ARFI

Objective

Transcranial magnetic resonance imaging (MRI)-guided histotripsy has been demonstrated to treat various locations in in vivo swine brain through a human skull. To ensure that the histotripsy treatment is delivered to the intended target location, accurate pre-treatment targeting is necessary. In this work, we investigate the feasibility of MR-thermometry and MR-acoustic radiation force imaging (MR-ARFI) to perform pre-treatment targeting of histotripsy in ex vivo bovine brain through a human skull.

Methods

A 700 kHz, 128-element MR-compatible histotripsy array was used to generate histotripsy and tone-burst sonications. The array's electronic drivers were modified to also generate low-amplitude tone-burst sonications to perform MR-thermometry and MR-ARFI–based targeting. Twelve ex vivo bovine brains were treated with histotripsy at 35 MPa, 75 MPa and through a skull at 36 MPa. Before treating the tissue, both MR-ARFI and MR-thermometry were used to estimate the lesion location. Finally, the location of the histotripsy lesion was compared with the focus estimated by MR-thermometry and MR-ARFI.

Results

MR-thermometry and MR-ARFI were able to successfully perform pre-treatment targeting of histotripsy using the modified histotripsy array driver. Histotripsy focus was estimated with mean absolute errors along the transverse/longitudinal axis of 2.06/2.95 mm and 2.13/2.51 mm for MR-ARFI and MR-thermometry, respectively. The presence of the human skull reduced the pressure at the focal region, but it did not compromise the targeting accuracy of either of the two methods with a mean absolute error of 1.10/2.91 mm and 1.29/2.91 mm for MR-ARFI and MR-thermometry, respectively.

Conclusion

This study demonstrated that transcranial histotripsy pre-treatment targeting is feasible with MR-thermometry and MR-ARFI.

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.