在两名患有手足口病和神经系统并发症的乌拉圭儿童中鉴定出新出现的肠道病毒 A71 的 C1 样系。

IF 3.8 3区 医学 Q2 VIROLOGY
Viruses-Basel Pub Date : 2024-11-08 DOI:10.3390/v16111752
Andrés Lizasoain, Natalia Martínez, Carla de Mora, Edivia Rodríguez, Nathalie Ledezma, Rodney Colina
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引用次数: 0

摘要

肠道病毒 A71(EV-A71)是手足口病(HFMD)的主要病因,尤其是在出现影响神经系统或心肺功能的并发症时。在南美洲,EV-A71 主要是通过对急性弛缓性麻痹 (AFP) 和其他神经系统疾病的研究发现的。2022 年 9 月,乌拉圭一个小城市的两名儿童因推测患有流行性脑炎而住院,表现出手足口病的症状。通过对粪便和皮肤病变样本进行 RT-PCR 和新一代测序,确定了 EV-A71。通过对 P1 编码区进行最大似然系统发生学分析,将乌拉圭的菌株归入了一个新出现的品系,该品系在过去十年中主要在欧洲报告,被称为 C1-like 品系。本文的研究结果是首次在南美洲报告的手足口病和脑炎病例中检测到 EV-A71 C1 样系,这突出表明,面临挑战的国家急需加强对手足口病、无菌性脑膜炎、脑炎和甲胎蛋白的监测,以建立与肠道病毒和相关疾病有关的有效监测计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of the Emerging C1-like Lineage of Enterovirus A71 in Two Uruguayan Children with Hand-Foot-and-Mouth Disease and Neurological Complications.

Enterovirus A71 (EV-A71) is a major cause of hand-foot-and-mouth disease (HFMD), particularly in cases that involve complications affecting the nervous system or cardiopulmonary function. In South America, EV-A71 has primarily been identified through studies of acute flaccid paralysis (AFP) and other neurological disorders. In September 2022, two children from a small city in Uruguay were hospitalized with presumptive rhombencephalitis, exhibiting symptoms of HFMD. EV-A71 was identified through RT-PCR and next-generation sequencing of stool and skin lesion samples. A maximum-likelihood phylogenetic analysis of the P1 coding region classified the Uruguayan strains as part of an emerging lineage, primarily reported in Europe over the past decade, known as the C1-like lineage. The findings presented here represent the first detection of the EV-A71 C1-like lineage in cases of HFMD and encephalitis reported from South America, underscoring the urgent need to enhance surveillance for HFMD, aseptic meningitis, encephalitis, and AFP, in countries facing challenges in establishing effective surveillance programs related to enteroviruses and associated diseases.

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来源期刊
Viruses-Basel
Viruses-Basel VIROLOGY-
CiteScore
7.30
自引率
12.80%
发文量
2445
审稿时长
1 months
期刊介绍: Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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