Francesco Bellinato, Maria Marocchi, Luca Pecoraro, Marco Zaffanello, Micol Del Giglio, Giampiero Girolomoni, Giorgio Piacentini, Erika Rigotti
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引用次数: 0
摘要
婴儿血管瘤(IHs)影响 3-10% 的婴儿,其中 10% 的婴儿需要局部或全身β-受体阻滞剂治疗。普萘洛尔是治疗并发症风险较高的 IH 的首选药物。由于半数以上的 IH 会留下永久性印记,为减少后遗症,必须在婴儿出生后第 5 个月(即增殖期)开始口服普萘洛尔(2-3 毫克/千克/天,2 次/天),并完成至少 6 个月的治疗周期。本综述旨在总结 IHs 的流行病学、临床表现、诊断和治疗,并强调适当转诊至专科枢纽中心的重要性。血管异常患者,尤其是怀疑患有 IH 的患者,应转诊到专科中心接受准确诊断、多学科团队管理和及时治疗。IH可能会危及生命、影响功能和美观,或导致溃疡。面部/颈部和腰骶部的节段性婴儿血管瘤可能与各种畸形有关。为确保及时进行专科评估和治疗,降低潜在的并发症风险,必须迅速识别高风险的婴儿血管瘤。婴儿血管瘤转诊评分表(IHReS)是协助初级儿科医生和普通皮肤科医生的重要工具。
Diagnosis and Treatment of Infantile Hemangioma from the Primary Care Paediatricians to the Specialist: A Narrative Review.
Infantile haemangiomas (IHs) affect 3-10% of infants, 10% of whom need topical or systemic beta-blocker therapy. Propranolol is the first choice for IHs with a high risk of complications. Since more than half of IHs leave a permanent mark, to reduce outcomes, it is essential to start oral propranolol (2-3 mg/kg/day in 2 doses/day) within the 5th month of life (i.e., during the proliferative phase) and to complete the therapy cycle for at least 6 months. This review aims to summarise the epidemiology, clinical presentation, diagnosis, and treatment of IHs and to highlight the importance of proper referral to specialised hub centres. Patients with vascular anomalies, particularly those suspected of having IH, should be referred to a specialised centre for accurate diagnosis, management by a multidisciplinary team, and timely treatment. IHs may pose life-threatening, functional, and aesthetic risks or may ulcerate. Segmental infantile haemangioma of the face/neck and the lumbosacral regions can be associated with various malformations. To ensure timely specialist evaluation and treatment to reduce the potential risk of complications, it is essential to identify high-risk IHs rapidly. The Infantile Haemangioma Referral Score (IHReS) scale is an important tool to assist primary care paediatricians and general dermatologists.
期刊介绍:
Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries.
The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.