Raul de la Puente, Raquel Diez, M Jose Diez, Nelida Fernandez, Ana M Sahagun, Jose M Rodriguez, Juan J Garcia, Cristina Lopez
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引用次数: 0
摘要
美洛昔康(Meloxicam)是一种非甾体抗炎药,属于奥昔康(oxicam)类。它具有消炎、镇痛和解热作用,被广泛应用于人类和兽医领域。美洛昔康对骨关节炎、肌肉骨骼疾病、急性呼吸道感染、产褥败血症、乳腺炎和乳腺炎-甲状腺炎-无乳综合征等疾病具有很高的治疗潜力。虽然美洛昔康的药代动力学已在许多物种中得到描述,但还没有一篇论文对这一领域的现有文献进行总结。因此,本综述的目的是对不同动物物种的美洛昔康药代动力学文献进行综述,并将数据收集在一篇综述文章中。我们对 PubMed、Web of Science 和 Scopus 数据库中的现有文献进行了全面回顾。在大多数动物物种中,口服和肠外给药后美洛昔康显示出良好的生物利用度(85-95%),其中绵羊口服给药后的生物利用度最低。由于美洛昔康在生理 pH 值下的电离状态相对较高,且与血浆蛋白的结合率较高(接近 99%),因此分布迅速,分布容积较小。美洛昔康在肝脏中被广泛代谢为几种非活性极性代谢物,这些代谢物与未改变的美洛昔康一样通过尿液和粪便排出体外。美洛昔康的消除半衰期长,清除率低。
Pharmacokinetics of Meloxicam in Different Animal Species: A Comprehensive Review.
Meloxicam is a non-steroidal anti-inflammatory in the oxicam group. It has been extensively used in human and veterinary medicine for their anti-inflammatory, analgesic and antipyretic activities. Meloxicam has shown high therapeutic potential for disorders such as osteoarthritis, musculoskeletal disorder, acute respiratory infection, puerperal septicemia, mastitis and mastitis-metritis-agalactia syndrome. Although meloxicam pharmacokinetic has been described for numerous species, no paper summarizes the existing literature on this field. Thus, the aim of this review was to carry out a review of the literature on the pharmacokinetics of meloxicam in different animal species and gather the data in a single review article. A comprehensive review of the available literature in the PubMed, Web of Science and Scopus databases was performed. Meloxicam shows good bioavailability after oral and parenteral administration in most animal species (85-95%), with the lowest values in sheep after oral administration. It presents a rapid distribution with a small volume of distribution, which can be attributed to relatively high ionization state of meloxicam at physiological pH and its high plasma protein binding (close to 99%). It is extensively metabolized in the liver in several inactive polar metabolites, which are excreted, like unchanged meloxicam in urine and feces. Meloxicam also shows a long elimination half-life and low clearance.
期刊介绍:
Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.