程序合法性:共同开发非洲疟疾控制遗传方法研究的社区协议模式。

IF 2.4 3区 医学 Q3 INFECTIOUS DISEASES
Naima Sykes, Jude Bigirwenkya, Isabelle Coche, Mouhammed Drabo, Divine Dzokoto, Samantha O'Loughlin, Lea Pare Toe, Alexandre Quach, Delphine Thizy
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引用次数: 0

摘要

过去几年中,疟疾负担的减轻停滞不前,基因驱动有望成为减少疾病传播的一种新方法。管理和决策过程是合法采用该技术的关键环节。在此,作者探讨了 "目标疟疾 "组织为释放非基因驱动转基因蚊子开发社区协议模式的历程。他们描述了该模式的迭代开发过程,包括咨询专家、利益相关者参与以及与程序正义原则保持一致。在开发过程中,他们发现了一些挑战,包括界定社区、确保足够的信息、咨询、监测,以及在反对观点和同意观点之间做出共同决定。这些挑战凸显了制定合法模式的复杂性,并强调了透明度、程序合法性和遵守道德原则的重要性。本文不描述模式本身,这将是另一篇论文的主题。本文将重点介绍这一过程,以便与其他项目--那些与基因驱动有关的项目或任何其他需要社区决策过程的项目--分享这一经验。该模型借鉴了 "目标疟疾 "项目在释放转基因雄性不育蚊子方面的经验,以应对转基因蚊子带来的挑战。转基因蚊子具有繁殖能力,因此预计会比雄性不育蚊子在环境中存活更长时间,传播更广。虽然这些非基因驱动但具有繁殖力的改良蚊子的传播水平和持久性预计将大大低于基因驱动蚊子,但这一过程是一个重要的进步,可以解决与基因驱动蚊子更持久的传播有关的更广泛的地理和时间问题。本文所描述的工作是社区协议程序演变的一部分,该程序可应用于为控制疟疾而释放基因驱蚊的建议。通过描述这一过程,"目标疟疾 "组织希望为正在进行的关于社区协议参与遗传病媒控制方法研究的良好做法的对话做出贡献,并分享在设计此类协议模式时建立合法性的经验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Procedural legitimacy: co-developing a community agreement model for genetic approaches research to malaria control in Africa.

With reductions in the malaria burden stalling in the past years, gene drive holds promise as a novel way of reducing disease transmission. Governance and decision-making processes are pivotal aspects of the legitimate adoption of this technology. Here, the authors explore Target Malaria's journey in developing a community agreement model for the release of non-gene drive genetically modified mosquitoes. They describe the iterative development of the model, including consultations with experts, stakeholder engagement, and alignment with principles of procedural justice. Several challenges were identified during its development, including defining communities, ensuring adequate information, consultation, monitoring, and achieving a common decision between dissenting and consenting viewpoints. They underscore the complexity of developing a legitimate model and emphasize the importance of transparency, procedural legitimacy, and adherence to ethical principles. This paper does not describe the model itself, which will be the subject of another paper. Instead it focuses on the process, to share this experience with other projects-those working with gene drive, or any other projects requiring a community-level decision-making process. The model builds on Target Malaria's experience with the release of genetically modified sterile male mosquitoes, to address the challenges posed by modified mosquitoes which are fertile and would therefore be expected to persist longer in the environment and spread further than the sterile male mosquito strains. While the level of spread and persistence of these non gene drive, but fertile, modified mosquitoes are expected to be substantially lower than those of the gene drive mosquitoes, the process is an essential advance in accommodating the broader geographical and temporal concerns associated with the more permanent spread of gene drive mosquitoes. The work described here constitutes part of the evolution of a community agreement process that could be applied to proposals for releases of gene drive mosquitoes for malaria control. In describing this process, Target Malaria hopes to contribute to the ongoing dialogue on good practices for community agreement engagement in research for genetic vector control approaches and to share the experience of building legitimacy while designing such agreement models.

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来源期刊
Malaria Journal
Malaria Journal 医学-寄生虫学
CiteScore
5.10
自引率
23.30%
发文量
334
审稿时长
2-4 weeks
期刊介绍: Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field.
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