Yue Song, Yachun Zhou, Mengjing Cong, Shengyi Deng, Yushi Chen, Xiaoyan Pang, Yonghong Liu, Li Liao, Liang Yang, Junfeng Wang
{"title":"北极细菌淀粉样芽孢杆菌（Bacillus amyloliquefaciens SCSIO 41392）中新的 24 位元巨内酯及其抗病原性评估。","authors":"Yue Song, Yachun Zhou, Mengjing Cong, Shengyi Deng, Yushi Chen, Xiaoyan Pang, Yonghong Liu, Li Liao, Liang Yang, Junfeng Wang","doi":"10.3390/md22110484","DOIUrl":null,"url":null,"abstract":"<p><p>Three new 24-membered macrolactines, amylomacrolactines A-C (<b>1</b>-<b>3</b>), along with two known compounds <b>4</b> and <b>5</b>, were isolated from the Arctic bacteria <i>Bacillus amyloliquefaciens</i> SCSIO 41392. The configurations of <b>1</b>-<b>3</b> were assigned by a combination of coupling constants, NOESY, and analysis of MM2-optimized conformation, as well as by comparison with reports in the literature. Compounds <b>1</b> and <b>2</b> showed quorum sensing (QS) inhibitory activities against the <i>Pseudomonas aeruginosa (P. aeruginosa)</i> PQS system and suppressed PQS-regulated virulence factor pyocyanin synthesis. In addition, compounds <b>3</b>-<b>5</b> affected the production of another essential virulence factor, siderophore of pyoverdine (PVD), in <i>P. aeruginosa</i>. More importantly, compound <b>5</b> showed an anti-biofilm activity against <i>P. aeruginosa</i>. Altogether, the isolated compounds displayed multiple bacterial virulence inhibition activities, which is worthy of further exploration for novel analogues in antimicrobial drug development.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 11","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595553/pdf/","citationCount":"0","resultStr":"{\"title\":\"New 24-Membered Macrolactines from an Arctic Bacterium <i>Bacillus amyloliquefaciens</i> SCSIO 41392 and Their Anti-Pathogenicity Evaluation.\",\"authors\":\"Yue Song, Yachun Zhou, Mengjing Cong, Shengyi Deng, Yushi Chen, Xiaoyan Pang, Yonghong Liu, Li Liao, Liang Yang, Junfeng Wang\",\"doi\":\"10.3390/md22110484\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Three new 24-membered macrolactines, amylomacrolactines A-C (<b>1</b>-<b>3</b>), along with two known compounds <b>4</b> and <b>5</b>, were isolated from the Arctic bacteria <i>Bacillus amyloliquefaciens</i> SCSIO 41392. The configurations of <b>1</b>-<b>3</b> were assigned by a combination of coupling constants, NOESY, and analysis of MM2-optimized conformation, as well as by comparison with reports in the literature. Compounds <b>1</b> and <b>2</b> showed quorum sensing (QS) inhibitory activities against the <i>Pseudomonas aeruginosa (P. aeruginosa)</i> PQS system and suppressed PQS-regulated virulence factor pyocyanin synthesis. In addition, compounds <b>3</b>-<b>5</b> affected the production of another essential virulence factor, siderophore of pyoverdine (PVD), in <i>P. aeruginosa</i>. More importantly, compound <b>5</b> showed an anti-biofilm activity against <i>P. aeruginosa</i>. Altogether, the isolated compounds displayed multiple bacterial virulence inhibition activities, which is worthy of further exploration for novel analogues in antimicrobial drug development.</p>\",\"PeriodicalId\":18222,\"journal\":{\"name\":\"Marine Drugs\",\"volume\":\"22 11\",\"pages\":\"\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595553/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Marine Drugs\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/md22110484\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Marine Drugs","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/md22110484","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
New 24-Membered Macrolactines from an Arctic Bacterium Bacillus amyloliquefaciens SCSIO 41392 and Their Anti-Pathogenicity Evaluation.
Three new 24-membered macrolactines, amylomacrolactines A-C (1-3), along with two known compounds 4 and 5, were isolated from the Arctic bacteria Bacillus amyloliquefaciens SCSIO 41392. The configurations of 1-3 were assigned by a combination of coupling constants, NOESY, and analysis of MM2-optimized conformation, as well as by comparison with reports in the literature. Compounds 1 and 2 showed quorum sensing (QS) inhibitory activities against the Pseudomonas aeruginosa (P. aeruginosa) PQS system and suppressed PQS-regulated virulence factor pyocyanin synthesis. In addition, compounds 3-5 affected the production of another essential virulence factor, siderophore of pyoverdine (PVD), in P. aeruginosa. More importantly, compound 5 showed an anti-biofilm activity against P. aeruginosa. Altogether, the isolated compounds displayed multiple bacterial virulence inhibition activities, which is worthy of further exploration for novel analogues in antimicrobial drug development.
期刊介绍：
Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
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