肺癌中 EBV 病毒与细胞代谢的相互作用

IF 5.3

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Pub Date : 2024-11-27 DOI:10.1111/jcmm.70088

Hongwei Wang

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引用次数: 0

摘要

爱泼斯坦-巴氏病毒感染与包括肺癌在内的多种癌症有关，它影响细胞代谢，促进肿瘤发生。这篇综述探讨了肺癌中 Epstein-Barr 病毒与细胞代谢之间复杂的相互作用，强调了代谢重编程的病毒机制及其对治疗策略的影响。LMP1和LMP2A等关键病毒蛋白操纵糖酵解、谷氨酰胺酵解和脂质代谢，以支持病毒复制和肿瘤微环境中的免疫逃避。了解了这些相互作用，就能深入了解针对 Epstein-Barr 病毒相关肺癌中病毒诱导的代谢脆弱性的新型治疗方法。

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The interplay of EBV virus and cell metabolism in lung cancer

Epstein–Barr virus infection has been implicated in various cancers, including lung cancer, where it influences cellular metabolism to promote tumorigenesis. This review examines the complex interplay between Epstein–Barr virus and cell metabolism in lung cancer, highlighting viral mechanisms of metabolic reprogramming and their implications for therapeutic strategies. Key viral proteins such as LMP1 and LMP2A manipulate glycolysis, glutaminolysis and lipid metabolism to support viral replication and immune evasion within the tumour microenvironment. Understanding these interactions provides insights into novel therapeutic approaches targeting viral-induced metabolic vulnerabilities in Epstein–Barr virus-associated lung cancer.

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来源期刊

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CiteScore

11.50

自引率

0.00%

发文量

期刊介绍： The Journal of Cellular and Molecular Medicine serves as a bridge between physiology and cellular medicine, as well as molecular biology and molecular therapeutics. With a 20-year history, the journal adopts an interdisciplinary approach to showcase innovative discoveries. It publishes research aimed at advancing the collective understanding of the cellular and molecular mechanisms underlying diseases. The journal emphasizes translational studies that translate this knowledge into therapeutic strategies. Being fully open access, the journal is accessible to all readers.