Michael Theron, Alexis Blasselle, Lisa Nedellec, Pascal Ballet, Emmanuel Dugrenot, Bernard Gardette, François Guerrero, Anne Henckes, Jean-Pierre Pennec
{"title":"高压氧环境中的 N2 交换:建立基于生理气体运输(O2 和 CO2)的模型。","authors":"Michael Theron, Alexis Blasselle, Lisa Nedellec, Pascal Ballet, Emmanuel Dugrenot, Bernard Gardette, François Guerrero, Anne Henckes, Jean-Pierre Pennec","doi":"10.1152/japplphysiol.00357.2024","DOIUrl":null,"url":null,"abstract":"<p><p>Decompression sickness can occur in divers even when recommended decompression procedures are followed. Furthermore, the physiological state of individuals can significantly affect bubbling variability. These informations highlight the need for personalized input to improve decompression in SCUBA diving. The main objective of this study is to propose a fundamental framework for a new approach to inert gas exchanges. A physiological model of oxygen delivery to organs and tissues has been built and adapted to nitrogen. The validation of the model was made by transferring the N<sub>2</sub> to CO<sub>2</sub>. Under normobaric conditions (air breathing, oxygen breathing, and static apnea) and hyperbaric conditions, the O<sub>2</sub> model replicates the reference physiological Po<sub>2</sub> (Spearman correlation tests p<0.001). The inert gas models can simulate inert gas partial pressures under normobaric and hyperbaric conditions. However, the lack of reference values prevents direct validation of this new model. Therefore, the N<sub>2</sub> model has been transferred to CO<sub>2</sub>. The resulting CO<sub>2</sub> model has been validated by comparing it with physiological reference values (Spearman correlation tests p<0.01). The validity of the CO<sub>2</sub> model constructed from the N<sub>2</sub> model demonstrates the plausibility of this physiological model of inert gas exchanges. In the context of personalized decompression procedures, the proposed model is of significant interest as it enables the integration of physiological and morphological parameters (blood and respiratory flows, alveolo-capillary diffusion, respiratory and blood volumes, oxygen consumption rate, fat mass, etc.) into a model of nitrogen saturation/desaturation, in which oxygen and CO<sub>2</sub> partial pressures can also be incorporated.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"N<sub>2</sub> exchanges in hyperbaric environments: towards a model based on physiological gas transport (O<sub>2</sub> and CO<sub>2</sub>).\",\"authors\":\"Michael Theron, Alexis Blasselle, Lisa Nedellec, Pascal Ballet, Emmanuel Dugrenot, Bernard Gardette, François Guerrero, Anne Henckes, Jean-Pierre Pennec\",\"doi\":\"10.1152/japplphysiol.00357.2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Decompression sickness can occur in divers even when recommended decompression procedures are followed. Furthermore, the physiological state of individuals can significantly affect bubbling variability. These informations highlight the need for personalized input to improve decompression in SCUBA diving. The main objective of this study is to propose a fundamental framework for a new approach to inert gas exchanges. A physiological model of oxygen delivery to organs and tissues has been built and adapted to nitrogen. The validation of the model was made by transferring the N<sub>2</sub> to CO<sub>2</sub>. Under normobaric conditions (air breathing, oxygen breathing, and static apnea) and hyperbaric conditions, the O<sub>2</sub> model replicates the reference physiological Po<sub>2</sub> (Spearman correlation tests p<0.001). The inert gas models can simulate inert gas partial pressures under normobaric and hyperbaric conditions. However, the lack of reference values prevents direct validation of this new model. Therefore, the N<sub>2</sub> model has been transferred to CO<sub>2</sub>. The resulting CO<sub>2</sub> model has been validated by comparing it with physiological reference values (Spearman correlation tests p<0.01). The validity of the CO<sub>2</sub> model constructed from the N<sub>2</sub> model demonstrates the plausibility of this physiological model of inert gas exchanges. 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N2 exchanges in hyperbaric environments: towards a model based on physiological gas transport (O2 and CO2).
Decompression sickness can occur in divers even when recommended decompression procedures are followed. Furthermore, the physiological state of individuals can significantly affect bubbling variability. These informations highlight the need for personalized input to improve decompression in SCUBA diving. The main objective of this study is to propose a fundamental framework for a new approach to inert gas exchanges. A physiological model of oxygen delivery to organs and tissues has been built and adapted to nitrogen. The validation of the model was made by transferring the N2 to CO2. Under normobaric conditions (air breathing, oxygen breathing, and static apnea) and hyperbaric conditions, the O2 model replicates the reference physiological Po2 (Spearman correlation tests p<0.001). The inert gas models can simulate inert gas partial pressures under normobaric and hyperbaric conditions. However, the lack of reference values prevents direct validation of this new model. Therefore, the N2 model has been transferred to CO2. The resulting CO2 model has been validated by comparing it with physiological reference values (Spearman correlation tests p<0.01). The validity of the CO2 model constructed from the N2 model demonstrates the plausibility of this physiological model of inert gas exchanges. In the context of personalized decompression procedures, the proposed model is of significant interest as it enables the integration of physiological and morphological parameters (blood and respiratory flows, alveolo-capillary diffusion, respiratory and blood volumes, oxygen consumption rate, fat mass, etc.) into a model of nitrogen saturation/desaturation, in which oxygen and CO2 partial pressures can also be incorporated.
期刊介绍:
The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.