一项横断面观察研究,将女性型脱发的三腔镜检查结果与疾病严重程度和潜在的组织病理学变化联系起来。

Q2 Medicine
International Journal of Trichology Pub Date : 2023-11-01 Epub Date: 2024-10-07 DOI:10.4103/ijt.ijt_40_22
Shreya Singh, Meena B Makhecha, Kinjal Deepak Rambhia
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引用次数: 0

摘要

背景:女性脱发(FPHL)发病率的不断上升令人担忧。三镜检查是诊断 FPHL 的重要床旁诊断工具,但很少有研究将三镜检查与疾病严重程度或组织病理学结果相关联,这将为临床医生提供更好的见解。因此,我们决定开展这项研究。目的:本研究旨在研究 FPHL 的三镜检查结果,并将其与疾病严重程度和组织病理学发现的关系联系起来:90名在皮肤科门诊就诊、临床诊断为FPHL的女性在知情同意并获得机构伦理委员会批准后被纳入研究。随后进行了详细的病史、临床检查和三镜检查评估。在三腔镜引导下从两个部位进行活组织检查。数据收集后,使用的统计软件是 IBM SPSS 21.0 版和 Microsoft Office Excel 2007。P<0.05为差异有统计学意义:结果:异形毛发增多、毛囊间距增大和每个毛囊单位毛发减少是普遍现象。棕色毛周征与炎症呈正相关(P < 0.0005),白色毛周征与病程和纤维化呈正相关,而镖盘征与炎症和纤维化呈显著相关:三腔镜检查有助于诊断病情、评估严重程度和监测治疗反应。了解炎症和纤维化等特定三腔镜体征的基本特征有助于临床医生决定治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Cross-sectional Observational Study to Correlate the Trichoscopic Findings of Female Pattern Hair Loss with the Disease Severity and Underlying Histopathological Changes.

Background: The increasing prevalence of female pattern hair loss (FPHL) is an alarming concern. Trichoscopy is an important bedside diagnostic tool for the diagnosis of FPHL, but there are very few studies correlating it with disease severity or histopathological findings which would provide a better insight to the treating clinician. Hence, we decided to take up this study.

Aim: This study aimed to study the trichoscopic findings of FPHL and correlate their relationship with disease severity and histopathological finding in our tertiary care hospital.

Materials and methods: Ninety females attending the dermatology outpatient department who were clinically diagnosed with FPHL were included in the study after informed consent and clearance from the institutional ethics committee. This was followed by a detailed history, clinical examination, and trichoscopic assessment. A trichoscopy-guided biopsy was performed from two sites. After the data collection, the statistical software used was IBM SPSS version 21.0 and Microsoft Office Excel 2007. P < 0.05 was accepted as indicative of statistical significance.

Results: Anisotrichosis, increased interfollicular distance, and decreased hairs per follicular unit were universal. Brown peripilar sign had a positive association with inflammation (P < 0.0005) and white peripilar sign with duration of disease and fibrosis whereas dartboard sign had a significant association with inflammation as well as fibrosis.

Conclusion: Trichoscopy helps in diagnosing the condition, assessing the severity, and monitoring the response to treatment. A knowledge about the features underlying specific trichoscopic signs such as inflammation and fibrosis would help the clinician decide the line of management.

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CiteScore
1.50
自引率
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发文量
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