肝硬化合并糖尿病患者经颈静脉肝内门体分流术后发生肝性脑病的独立风险因素分析。

IF 2.3 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

European Journal of Gastroenterology & Hepatology Pub Date : 2025-02-01 Epub Date: 2024-11-15 DOI:10.1097/MEG.0000000000002889

Huan Chen, Zihao Cai, Binlin Da, Chunxiang Wang, Qin Yin, Jiangqiang Xiao, Ming Zhang, Yuzheng Zhuge, Feng Zhang

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引用次数: 0

摘要

研究目的本研究旨在揭示失代偿期肝硬化合并糖尿病患者经颈静脉肝内门体分流术（TIPS）后出现明显肝性脑病（OHE）的独立危险因素：本研究回顾性分析了2016年1月至2022年6月在我科接受TIPS治疗的126例肝硬化合并糖尿病患者。根据 TIPS 术后是否出现 OHE 将患者分为两组。数据分析采用χ2检验、非配对t检验、Logistic回归、接收者操作特征曲线和Kaplan-Meier曲线：结果：年龄和腹水是肝硬化和糖尿病患者 TIPS 术后发生 OHE 的独立危险因素。老年患者术后发生OHE的风险高于年轻患者[几率比（OR）：1.040；95% 置信区间（CI）：1.003-1.079]。与没有腹水的患者相比，有腹水的患者发生 OHE 的几率明显更高（OR：3.757；95% CI：1.274-11.080；OR：4.338；95% CI：1.069-17.603）：结论：年龄和腹水是糖尿病肝硬化患者发生 TIPS 后 OHE 的独立危险因素。

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Analysis of independent risk factors for hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis combined with diabetes.

Objective: This study aimed to reveal the independent risk factors for overt hepatic encephalopathy (OHE) after transjugular intrahepatic portosystemic shunt (TIPS) in patients with decompensated cirrhosis complicated with diabetes.

Patients and methods: This study retrospectively analyzed 126 consecutive patients with cirrhosis combined with diabetes who underwent TIPS in our department from January 2016 to June 2022. The patients were divided into two groups according to the presence or absence of OHE after TIPS. Data were analyzed using the χ 2 -tests, unpaired t -tests, logistic regression, receiver operating characteristic curves, and Kaplan-Meier curves.

Results: Age and ascites were independent risk factors for OHE after TIPS in patients with cirrhosis and diabetes. Elder patients had a higher risk of postoperative OHE than younger patients [odds ratio (OR): 1.040; 95% confidence interval (CI): 1.003-1.079]. Compared with patients without ascites, patients with ascites were significantly more likely to develop OHE (OR: 3.757; 95% CI: 1.274-11.080; OR: 4.338; 95% CI: 1.069-17.603).

Conclusion: Age and ascites are independent risk factors of post-TIPS OHE in cirrhotic patients with diabetes.

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来源期刊

European Journal of Gastroenterology & Hepatology 医学-胃肠肝病学

CiteScore

4.40

自引率

4.80%

发文量

269

审稿时长

1 months

期刊介绍： European Journal of Gastroenterology & Hepatology publishes papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The journal publishes three types of manuscript: in-depth reviews (by invitation only), full papers and case reports. Manuscripts submitted to the journal will be accepted on the understanding that the author has not previously submitted the paper to another journal or had the material published elsewhere. Authors are asked to disclose any affiliations, including financial, consultant, or institutional associations, that might lead to bias or a conflict of interest.