中国人感染甲型 H10N3 流感病毒的来源、致病性和传播性。

IF 8.4 2区医学 Q1 IMMUNOLOGY

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2024-12-09 DOI:10.1080/22221751.2024.2432364

Wenfei Zhu, Lei Yang, Xue Han, Min Tan, Shumei Zou, Xiyan Li, Weijuan Huang, Xiaoxu Zeng, Dayan Wang

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引用次数: 0

摘要

摘要 H10 亚型病毒已知可在非洲、大洋洲和亚洲感染人类。2021年、2022年以及最近的2024年4月，发现了一种新型H10N3亚型禽流感病毒，该病毒可导致人类感染并引发重症肺炎。在此，我们全面研究了新出现的甲型 H10N3 流感病毒的系统进化和生物学特征。我们发现，人类分离到的 H10N3 病毒于 2019 年初在家禽中产生。病毒与水杨酸α2、3受体结合，表明其感染人类的能力不足。人分离的H10N3病毒虽然是一种低致病性禽流感病毒，但在BALB/c和C57BL/6小鼠中都表现出很强的致病性，MLD50比同源环境分离株高出1000倍。人类分离的 H10N3 病毒在雪貂间也表现出呼吸飞沫传播性。考虑到 H10 亚型病毒在禽类群体中的持续传播和对人类的反复传播，应加强对家禽中 H10 亚型病毒的监测。

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Origin, pathogenicity, and transmissibility of a human isolated influenza A(H10N3) virus from China.

Subtype H10 viruses are known to infect humans in Africa, Oceania, and Asia. In 2021, 2022, and recently in April 2024, a novel H10N3 subtype avian influenza virus was found cause human infection with severe pneumonia. Herein, we comprehensively studied the phylogenetic evolution and biological characteristics of the newly emerged influenza A(H10N3) virus. We found that the human isolated H10N3 virus was generated in early 2019 in domestic poultry. The viruses bound to salic acid α2, 3 receptors, indicating their insufficient ability to infect humans. Although a low pathogenic avian influenza virus, the human isolated H10N3 virus exhibited robust pathogenicity in both BALB/c and C57BL/6 mice, with MLD₅₀ 1000 times higher than a homologous environmental isolate. The human isolated H10N3 also showed respiratory droplet transmissibility in ferrets. Considering the continuous circulation in avian populations and repeated transmission to humans, strengthened surveillance of H10 subtype viruses in poultry should be put into effect.

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.