{"title":"慢性糖尿病伤口中 pH 值和离子环境的影响:一个被忽视的视角","authors":"Jing Guo, Yi Cao, Qing-Yuan Wu, Yi-Mai Zhou, Yuan-Hao Cao, Lu-Sha Cen","doi":"10.2147/CCID.S485138","DOIUrl":null,"url":null,"abstract":"<p><p>The high incidence of disability and fatality rates associated with chronic diabetic wounds are difficult problems in the medical field. The steady-state and regular changes of the microenvironment in and around the wound provide good conditions for wound healing and achieve a dynamic and complex process of wound healing.The pH value and ionic environment composed of a variety of ions in wound are important factors affecting the wound microenvironment, and there are direct or indirect connections between them. Abnormalities in pH, ion concentrations, and channels in skin tissue may be one of the reasons for the high incidence and difficulty in chronic diabetic wounds healing. Currently, different wound-dressing applications have been developed based on the efficacy of ions. Here, the effect of pH in wounds, concentrations of calcium (Ca<sup>2+</sup>), sodium (Na<sup>+</sup>), potassium (K<sup>+</sup>) and the metal ions silver (Ag<sup>+</sup>), copper (Cu<sup>2+</sup>), iron (Fe<sup>2+</sup>/Fe<sup>3+</sup>), zinc (Zn<sup>2+</sup>), and magnesium (Mg<sup>2+</sup>) in skin tissue, their roles in wound healing, and the application of related dressings are reviewed. This manuscript provides new ideas and approaches for future clinical and basic research examining the treatment of chronic diabetic wounds by adjusting ion concentrations and channels.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2669-2686"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590674/pdf/","citationCount":"0","resultStr":"{\"title\":\"Implications of pH and Ionic Environment in Chronic Diabetic Wounds: An Overlooked Perspective.\",\"authors\":\"Jing Guo, Yi Cao, Qing-Yuan Wu, Yi-Mai Zhou, Yuan-Hao Cao, Lu-Sha Cen\",\"doi\":\"10.2147/CCID.S485138\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The high incidence of disability and fatality rates associated with chronic diabetic wounds are difficult problems in the medical field. The steady-state and regular changes of the microenvironment in and around the wound provide good conditions for wound healing and achieve a dynamic and complex process of wound healing.The pH value and ionic environment composed of a variety of ions in wound are important factors affecting the wound microenvironment, and there are direct or indirect connections between them. Abnormalities in pH, ion concentrations, and channels in skin tissue may be one of the reasons for the high incidence and difficulty in chronic diabetic wounds healing. Currently, different wound-dressing applications have been developed based on the efficacy of ions. Here, the effect of pH in wounds, concentrations of calcium (Ca<sup>2+</sup>), sodium (Na<sup>+</sup>), potassium (K<sup>+</sup>) and the metal ions silver (Ag<sup>+</sup>), copper (Cu<sup>2+</sup>), iron (Fe<sup>2+</sup>/Fe<sup>3+</sup>), zinc (Zn<sup>2+</sup>), and magnesium (Mg<sup>2+</sup>) in skin tissue, their roles in wound healing, and the application of related dressings are reviewed. This manuscript provides new ideas and approaches for future clinical and basic research examining the treatment of chronic diabetic wounds by adjusting ion concentrations and channels.</p>\",\"PeriodicalId\":10447,\"journal\":{\"name\":\"Clinical, Cosmetic and Investigational Dermatology\",\"volume\":\"17 \",\"pages\":\"2669-2686\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590674/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical, Cosmetic and Investigational Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/CCID.S485138\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical, Cosmetic and Investigational Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CCID.S485138","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Implications of pH and Ionic Environment in Chronic Diabetic Wounds: An Overlooked Perspective.
The high incidence of disability and fatality rates associated with chronic diabetic wounds are difficult problems in the medical field. The steady-state and regular changes of the microenvironment in and around the wound provide good conditions for wound healing and achieve a dynamic and complex process of wound healing.The pH value and ionic environment composed of a variety of ions in wound are important factors affecting the wound microenvironment, and there are direct or indirect connections between them. Abnormalities in pH, ion concentrations, and channels in skin tissue may be one of the reasons for the high incidence and difficulty in chronic diabetic wounds healing. Currently, different wound-dressing applications have been developed based on the efficacy of ions. Here, the effect of pH in wounds, concentrations of calcium (Ca2+), sodium (Na+), potassium (K+) and the metal ions silver (Ag+), copper (Cu2+), iron (Fe2+/Fe3+), zinc (Zn2+), and magnesium (Mg2+) in skin tissue, their roles in wound healing, and the application of related dressings are reviewed. This manuscript provides new ideas and approaches for future clinical and basic research examining the treatment of chronic diabetic wounds by adjusting ion concentrations and channels.
期刊介绍:
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.