未服药的注意力缺陷/多动障碍儿童的动态功能结构稳定性异常。

IF 3.4 2区 医学 Q2 PSYCHIATRY
Shuangli Chen, Beihui Xue, Ronghui Zhou, Andan Qian, Jiejie Tao, Chuang Yang, Xiaoqi Huang, Meihao Wang
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引用次数: 0

摘要

背景和目的:注意缺陷/多动障碍(ADHD)是儿童期最常见的神经发育障碍,以发育不适当的注意力不集中和/或多动/冲动症状为特征。静态和动态功能连接(FC)研究揭示了多动症的大脑功能障碍。然而,很少有研究对ADHD儿童动态功能结构的稳定性进行估计。本研究试图确定与药物治疗前儿童多动症相关的功能稳定性(FS)异常:收集了42名ADHD儿童和30名健康对照组(HCs)的静息态fMRI数据。采用滑动窗口法,通过测量动态FC随时间变化的一致性获得每个体素的FS。此外,还进行了基于种子的动态FC(dFC)研究,以探索与FS改变相关的dFC改变的特定脑区。然后,进行组间比较和相关分析:结果:我们发现多动症儿童表现出:(1)双侧额上回(SFG)的FS降低,右侧颞中回(MTG)的FS升高,这两个区域都属于默认模式网络(DMN);(2)DMN的双侧SFG与显著性网络(SN)的左侧岛叶之间的dFC升高(GRF,体素P 结论:我们的研究结果表明,多动症儿童的大脑功能结构异常,这与他们的 "默认模式网络"(DMN)和 "显著性网络"(SN)之间的dFC异常有关:我们的研究结果表明,多动症儿童的异常功能结构涉及 DMN(双侧 SFG 和右侧 MTG)和 SN(左侧脑岛)区域。这项初步研究为了解多动症的动态大脑功能网络提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Abnormal stability of dynamic functional architecture in drug-naïve children with attention-deficit/hyperactivity disorder.

Background and aims: Attention-deficit/hyperactivity disorder (ADHD) is most commonly diagnosed neurodevelopmental disorder in childhood, characterized by developmentally inappropriate inattention and/or hyperactivity/impulsivity symptoms. Static and dynamic functional connectivity (FC) studies have revealed brain dysfunction in ADHD. However, few studies have estimated the stability of dynamic functional architecture of children with ADHD. The present study attempted to identify the functional stability (FS) abnormalities associated with ADHD in drug-naïve children.

Materials and methods: The resting-state fMRI of 42 children with ADHD and 30 healthy controls (HCs) were collected. Using the sliding window approach, FS of each voxel was obtained by measuring the concordance of dynamic FC over time. Further, the seed based dynamic FC (dFC) was conducted to explore the specific brain regions with dFC alteration related to these brain regions with altered FS. Then, the inter-group comparison and correlation analysis were performed.

Results: We found that children with ADHD exhibited (1) decreased FS in the bilateral superior frontal gyrus (SFG) and increased FS in the right middle temporal gyrus (MTG), which both belong to the default mode network (DMN); (2) increased dFC between the bilateral SFG of DMN and the left insula of salience networks (SN) (GRF, voxel-wise p < 0.001, cluster-wise p < 0.05); (3) decreased dFC between the right MTG and the left cerebellum posterior lobe, and (3) worse performance in the Stroop test that significantly correlate with decreased FS in the bilateral SFG (p = 0.043, FDR corrected).

Conclusions: Our findings showed that the abnormal functional architecture involved the DMN (the bilateral SFG and right MTG) and SN (left insula) regions in children with ADHD. This preliminary study provides novel insight into the dynamic brain functional networks in ADHD.

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来源期刊
BMC Psychiatry
BMC Psychiatry 医学-精神病学
CiteScore
5.90
自引率
4.50%
发文量
716
审稿时长
3-6 weeks
期刊介绍: BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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