双重负担:探索慢性肾脏病的心血管并发症。

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2024-10-31 DOI:10.3390/biom14111393
Alfredo Caturano, Raffaele Galiero, Maria Rocco, Giuseppina Tagliaferri, Alessia Piacevole, Davide Nilo, Giovanni Di Lorenzo, Celestino Sardu, Vincenzo Russo, Erica Vetrano, Marcellino Monda, Raffaele Marfella, Luca Rinaldi, Ferdinando Carlo Sasso
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引用次数: 0

摘要

慢性肾脏病(CKD)是一项重大的全球性健康挑战,影响着数百万人,并导致大量的发病率和死亡率。本综述旨在探讨与 CKD 相关的流行病学、心血管并发症和管理策略,强调预防心血管疾病和早期干预的重要性。慢性肾功能衰竭主要是由糖尿病、高血压和心血管疾病等疾病引起的,这些疾病往往同时存在并加重肾功能损害。有效的管理需要采取多方面的方法,包括改变生活方式、药物干预和定期监测。饮食习惯的改变,如限制钠的摄入、控制磷和钾的摄入,在保护肾功能方面起着至关重要的作用。药物疗法,尤其是血管紧张素转换酶(ACE)抑制剂、血管紧张素受体阻滞剂(ARB)以及 SGLT2 抑制剂等新兴药物,在减缓疾病进展和改善患者预后方面已显示出疗效。此外,接受透析治疗的患者面临着更高的心血管风险,因此有必要采取全面的管理策略,同时兼顾肾脏和心脏健康。随着慢性肾功能衰竭治疗领域的不断发展,对新型治疗方案和个性化医疗方法的持续研究至关重要。这篇综述强调,迫切需要提高认识、开展教育和采取有效的预防措施,以减轻慢性肾功能衰竭的负担并提高患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Dual Burden: Exploring Cardiovascular Complications in Chronic Kidney Disease.

Chronic kidney disease (CKD) represents a significant global health challenge, affecting millions of individuals and leading to substantial morbidity and mortality. This review aims to explore the epidemiology, cardiovascular complications, and management strategies associated with CKD, emphasizing the importance of preventing cardiovascular disease and early intervention. CKD is primarily driven by conditions such as diabetes mellitus, hypertension, and cardiovascular diseases, which often coexist and exacerbate renal impairment. Effective management requires a multifaceted approach, including lifestyle modifications, pharmacological interventions, and regular monitoring. Dietary changes, such as sodium restriction and a controlled intake of phosphorus and potassium, play a vital role in preserving renal function. Pharmacological therapies, particularly angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and emerging agents like SGLT2 inhibitors, have shown efficacy in slowing disease progression and improving patient outcomes. Furthermore, patients undergoing dialysis face increased cardiovascular risk, necessitating comprehensive management strategies to address both renal and cardiac health. As the landscape of CKD treatment evolves, ongoing research into novel therapeutic options and personalized medical approaches are essential. This review underscores the urgent need for awareness, education, and effective preventive measures to mitigate the burden of CKD and enhance the quality of life for affected individuals.

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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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