代谢功能障碍相关性脂肪性肝病 (MASLD)、代谢性酒精相关性肝病 (MetALD) 和代谢功能障碍酒精性肝病 (ALD) 中的高敏 C-Reactive 蛋白水平。

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2024-11-18 DOI:10.3390/biom14111468
Seong-Uk Baek, Jin-Ha Yoon
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引用次数: 0

摘要

代谢功能障碍相关性脂肪性肝病(MASLD)是最近引入的脂肪性肝病(SLD)术语。尽管炎症过程是脂肪肝发病机制的核心,但对不同亚型脂肪肝的全身炎症差异以及性别差异的研究却很有限。这项基于人群的横断面研究调查了韩国成年人(N = 20,141 人;平均年龄:50.8 ± 16.7 岁)的 SLD 亚型与高敏 C 反应蛋白(hs-CRP)水平之间的关系。参与者被分为五组,包括无 SLD、MASLD、代谢性酒精相关肝病(MetALD)、代谢功能障碍酒精性肝病(ALD with MD)和其他 SLD。hs-CRP水平的中位数(Q1,Q3)为0.54毫克/升(0.33,1.04)。在男性中,与无 SLD 组的水平相比,MASLD、MetALD 和 ALD with MD 组的 hs-CRP 水平分别增加了 41.9%(95% 置信区间 [CI]:35.1-49.1%)、46.8%(95% 置信区间 [CI]:35.0-59.6%)和 51.8%(95% 置信区间 [CI]:30.0-77.2%)。与无 SLD 组的水平相比,MASLD、MetALD 和 ALD 伴 MD 组的 hs-CRP 水平分别增加了 81.5%(95% CI:73.6-89.8%)、84.3%(95% CI:58.1-114.8%)和 98.2%(95% CI:38.0-184.8%)。总之,我们的研究结果表明,SLD 亚型的全身炎症情况各不相同,SLD 妇女的 hs-CRP 水平增加更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-Sensitivity C-Reactive Protein Levels in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Alcohol-Associated Liver Disease (MetALD), and Alcoholic Liver Disease (ALD) with Metabolic Dysfunction.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a recently introduced term for steatotic liver disease (SLD). Although the inflammatory process is central to the pathogenesis of SLD, research investigating the differences in systemic inflammation across various SLD subtypes as well as sex differences is limited. This population-based, cross-sectional study investigated the association between SLD subtypes and high-sensitivity C-reactive protein (hs-CRP) levels among Korean adults (N = 20,141; mean age: 50.8 ± 16.7 years). The participants were classified into five groups that included no SLD, MASLD, metabolic alcohol-associated liver disease (MetALD), alcoholic liver disease with metabolic dysfunction (ALD with MD), and other SLDs. The median (Q1, Q3) value of the hs-CRP level was 0.54 mg/L (0.33, 1.04). Among men, compared to levels in the no SLD group, the MASLD, MetALD, and ALD with MD groups were associated with 41.9% (95% confidence interval [CI]: 35.1-49.1%), 46.8% (95% CI: 35.0-59.6%), and 51.8% (95% CI: 30.0-77.2%) increases in hs-CRP levels, respectively. The association between SLD subtypes and hs-CRP levels was stronger among women, and compared to the levels in the no SLD group, the MASLD, MetALD, and ALD with MD groups were associated with 81.5% (95% CI: 73.6-89.8%), 84.3% (95% CI: 58.1-114.8%), and 98.2% (95% CI: 38.0-184.8%) increases in hs-CRP levels, respectively. In conclusion, our findings indicate a varying profile of systemic inflammation across SLD subtypes, with more pronounced increases in hs-CRP levels in women with SLDs.

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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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