心外膜脂肪组织的心肌脂肪毒性

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-11-18 DOI:10.3390/biom14111465

Monica L Bodenstab, Ron T Varghese, Gianluca Iacobellis

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引用次数: 0

摘要

心外膜脂肪组织是一种独特的内脏脂肪组织库，在心肌代谢中起着至关重要的作用。心外膜脂肪组织是邻近心肌能量和游离脂肪酸的主要来源。然而，在病理条件下，心外膜脂肪会通过过量和异常的脂质流入影响心脏。心外膜脂肪组织对心脏的脂毒性是复杂的，涉及不同的途径，如炎症加剧、二酰甘油和神经酰胺等脂质中间产物的渗入、线粒体功能障碍和氧化应激，最终导致心肌细胞功能障碍和冠状动脉缺血。这些变化可导致各种心脏代谢疾病的发病，包括心房颤动、冠心病、心力衰竭和阻塞性睡眠呼吸暂停。因此，本综述讨论了心外膜脂肪的心肌脂毒性作用及其临床意义。

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Cardio-Lipotoxicity of Epicardial Adipose Tissue.

Epicardial adipose tissue is a unique visceral adipose tissue depot that plays a crucial role in myocardial metabolism. Epicardial adipose tissue is a major source of energy and free fatty acids for the adjacent myocardium. However, under pathological conditions, epicardial fat can affect the heart through the excessive and abnormal influx of lipids. The cardio-lipotoxicity of the epicardial adipose tissue is complex and involves different pathways, such as increased inflammation, the infiltration of lipid intermediates such as diacylglycerol and ceramides, mitochondrial dysfunction, and oxidative stress, ultimately leading to cardiomyocyte dysfunction and coronary artery ischemia. These changes can contribute to the pathogenesis of various cardio-metabolic diseases including atrial fibrillation, coronary artery disease, heart failure, and obstructive sleep apnea. Hence, the role of the cardio-lipotoxicity of epicardial fat and its clinical implications are discussed in this review.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.