癌症中的铁蛋白沉积：表观遗传学控制和治疗机会。

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-11-13 DOI:10.3390/biom14111443

Roberta Veglia Tranchese, Sabrina Battista, Laura Cerchia, Monica Fedele

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引用次数: 0

摘要

铁突变是一种由脂质过氧化驱动的铁依赖性细胞死亡形式，已成为癌症生物学中的一个重要途径。这篇综述深入探讨了调节癌细胞铁突变的表观遗传学机制，重点关注 DNA 甲基化、组蛋白修饰和非编码 RNA 如何影响参与这一过程的重要基因的表达和功能。通过揭示这些表观遗传机制与铁凋亡之间复杂的相互作用，文章揭示了新的基因靶点和功能见解，这些见解可为创新癌症治疗铺平道路，从而提高疗效并克服癌症治疗中的抗药性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities.

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical pathway in cancer biology. This review delves into the epigenetic mechanisms that modulate ferroptosis in cancer cells, focusing on how DNA methylation, histone modifications, and non-coding RNAs influence the expression and function of essential genes involved in this process. By unraveling the complex interplay between these epigenetic mechanisms and ferroptosis, the article sheds light on novel gene targets and functional insights that could pave the way for innovative cancer treatments to enhance therapeutic efficacy and overcome resistance in cancer therapy.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.