利用炎症和兴奋毒性体外模型评估全谱低 THC 大麻植物提取物的功效。

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-11-11 DOI:10.3390/biom14111434

Emily Ross-Munro, Esra Isikgel, Bobbi Fleiss

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引用次数: 0

摘要

越来越多的证据表明，从大麻中提取的化合物具有治疗自闭症谱系障碍等神经发育疾病中出现的神经炎症变化的潜力。然而，还需要对可用于商业生产的全株大麻提取物对大脑健康的具体益处进行研究。在这里，我们探讨了 NTI-164（一种基因独特的高大麻二酚（CBD）、低Δ9-四氢大麻酚提取物）以及单独使用 CBD 对 BV-2 小胶质细胞和 SHSY-5Y 神经元的抗炎和神经保护作用。NTI-164 能显著降低炎症诱导的小胶质细胞炎症标志物上调，而 CBD 则不能。在兴奋毒性条件下，NTI-164 能促进未分化神经元的增殖和分化神经元的存活。这些作用表明，NTI-164 具有治疗神经病变的潜力。

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Evaluation of the Efficacy of a Full-Spectrum Low-THC Cannabis Plant Extract Using In Vitro Models of Inflammation and Excitotoxicity.

Evidence has accumulated that Cannabis-derived compounds have the potential to treat neuroinflammatory changes present in neurodevelopmental conditions such as autism spectrum disorder. However, research is needed on the specific brain health benefits of strains of whole Cannabis extract that are ready for commercial production. Here, we explore the anti-inflammatory and neuroprotective effects of NTI-164, a genetically unique high-cannabidiol (CBD), low-Δ9-tetrahydrocannabinol extract, and also CBD alone on BV-2 microglia and SHSY-5Y neurons. Inflammation-induced up-regulation of microglial inflammatory markers was significantly attenuated by NTI-164, but not by CBD. NTI-164 promoted undifferentiated neuron proliferation and differentiated neuron survival under excitotoxic conditions. These effects suggest the potential for NTI-164 as a treatment for neuropathologies.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.