历代对癌症的看法--从希波克拉底肿瘤学到精准癌症医学。

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-10-30 DOI:10.3390/biom14111383

Spyros Retsas

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引用次数: 0

摘要

人类基因组的揭开，使人们对疾病的起源和进化有了新的认识，特别是对癌症而言，它确立了一种观念，即肿瘤自地球上出现以来就是生命的伴侣。在众多动物甚至植物物种中出现各种形式的肿瘤也就不足为奇了。公元前 5 世纪就有了关于癌症临床特征的明确记载，而希波克拉底和加利尼传统的原则和实践几乎主导了 20 世纪的癌症治疗。21 世纪初的先进测序技术为免疫疗法、溶瘤病毒疗法和基因转移带来了新的治疗机会，后者尤其适用于遗传性癌症。

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Perceptions of Cancer Through the Ages-From Hippocratic Oncology to Precision Cancer Medicine.

The unravelling of the human genome created new perceptions of the origin and evolution of diseases, and for cancer in particular, it established the notion that neoplasia has been a companion of life since its appearance on Earth. It is not surprising that neoplasms, in various forms, develop in numerous species of animals and even in plants. Unmistakable accounts of cancer with clinical features as are understood today begin in the 5th c. B.C. The principles and practice of the Hippocratic and Galenic tradition dominated cancer care virtually into the 20th century. Advanced sequencing technologies at the dawn of the 21st century generated new therapeutic opportunities with immunotherapy, oncolytic virotherapy, and gene transfer, with the latter especially being used in cases of hereditary cancer.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.