miRNA 在乳腺癌发生和发展中的作用:当前研究。

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioFactors Pub Date : 2024-11-27 DOI:10.1002/biof.2146
Sachin Kumar, Abhishek Ranga
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引用次数: 0

摘要

乳腺癌是一种影响全球众多女性的复杂而多变的疾病,一直是导致癌症相关死亡的主要原因。微小 RNA(miRNA)是一种小型非编码 RNA,因其参与乳腺癌的进展而备受关注。这些分子通过转录后调节基因表达,影响包括增殖、分化和凋亡在内的关键细胞过程。本综述概述了目前有关 miRNA 在乳腺癌中作用的研究。综述讨论了 miRNA 在乳腺癌中的作用,包括乳腺癌的不同亚型、其分子特征以及 miRNA 在乳腺癌细胞中调控基因表达的机制。此外,综述还重点介绍了最近的研究,这些研究确定了乳腺癌中调控失调的特定 miRNA,以及它们作为诊断和预后生物标志物的潜在用途。此外,综述还探讨了 miRNA 在乳腺癌治疗中的治疗潜力。临床前研究表明,以 miRNA 为基础的疗法(如抗组胺药物和 miRNA 模拟疗法)在抑制肿瘤生长和转移方面非常有效。此外,还讨论了一些新兴领域,包括应用人工智能(AI)推进 miRNA 研究,以及整合人类和动物癌症研究成果的 "一体健康 "方法。然而,在将这些疗法完全转化为临床实践之前,挑战依然存在。总之,本综述强调了 miRNA 在乳腺癌研究中的重要性及其作为创新诊断和治疗工具的潜力。深入了解乳腺癌中的 miRNA 失调对其在临床中的成功应用至关重要。随着研究的不断深入,基于 miRNA 的方法有望改善这种毁灭性疾病的患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of miRNAs in breast cancer development and progression: Current research.

Breast cancer, a complex and heterogeneous ailment impacting numerous women worldwide, persists as a prominent cause of cancer-related fatalities. MicroRNAs (miRNAs), small non-coding RNAs, have garnered significant attention for their involvement in breast cancer's progression. These molecules post-transcriptionally regulate gene expression, influencing crucial cellular processes including proliferation, differentiation, and apoptosis. This review provides an overview of the current research on the role of miRNAs in breast cancer. It discusses the role of miRNAs in breast cancer, including the different subtypes of breast cancer, their molecular characteristics, and the mechanisms by which miRNAs regulate gene expression in breast cancer cells. Additionally, the review highlights recent studies identifying specific miRNAs that are dysregulated in breast cancer and their potential use as diagnostic and prognostic biomarkers. Furthermore, the review explores the therapeutic potential of miRNAs in breast cancer treatment. Preclinical studies have shown the effectiveness of miRNA-based therapies, such as antagomir and miRNA mimic therapies, in inhibiting tumor growth and metastasis. Emerging areas, including the application of artificial intelligence (AI) to advance miRNA research and the "One Health" approach that integrates human and animal cancer insights, are also discussed. However, challenges remain before these therapies can be fully translated into clinical practice. In conclusion, this review emphasizes the significance of miRNAs in breast cancer research and their potential as innovative diagnostic and therapeutic tools. A deeper understanding of miRNA dysregulation in breast cancer is essential for their successful application in clinical settings. With continued research, miRNA-based approaches hold promise for improving patient outcomes in this devastating disease.

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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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