协调化合物作为抗病毒药物防治被忽视的热带疾病。

IF 3.6 4区 医学 Q2 CHEMISTRY, MEDICINAL
ChemMedChem Pub Date : 2024-11-26 DOI:10.1002/cmdc.202400799
Wallace S Rezende, Antonio Marçal Neto, Juliano J Corbi, Pedro P Corbi, Raphael E F de Paiva, Fernando R G Bergamini
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引用次数: 0

摘要

被忽视的热带病毒性疾病是社会和经济福利的负担,造成了较高的病原体相关死亡率和病人的慢性衰弱状况。气候的变化扩大了这类疾病的感染率,在以前的温带至寒带环境中出现了自体传播。潜在疫苗的开发进展缓慢,而治疗此类疾病的抗病毒药物又缺乏,这大大加剧了疾病的蔓延。配位化合物是一类已被广泛探索用作抗病毒药物的分子,如脊髓灰质炎病毒、艾滋病病毒,以及最近的 SARS-CoV-2 病毒。本综述介绍了目前无机药物化学在应对被忽视的热带病毒性疾病方面所做的努力,重点是配位化合物。由于许多被忽视的病毒也是节肢动物传播的病毒,依赖于载体进行传播,因此还介绍了能够缓解载体的配位实体,作为预防和控制此类疾病的并行策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coordination Compounds as Antivirals against Neglected Tropical Diseases.

Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen-related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate-to-cold environments. The slow-paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation. Coordination compounds are a class of molecules that have been extensively explored as antiviral drugs for viruses such as poliovirus, HIV and, more recently, SARS-CoV-2, figuring as potential molecules to be explored and capitalized as antivirals against neglected viral strains. In this review the current efforts from the inorganic medicinal chemistry to address viral neglected tropical diseases, with emphasis to coordination compounds, is presented. Since many of neglected viruses are also arthropod-borne viruses, relying on a vector for transmission, coordination entities able to mitigate vectors are also presented as a parallel strategy to prevent and control such diseases.

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来源期刊
ChemMedChem
ChemMedChem 医学-药学
CiteScore
6.70
自引率
2.90%
发文量
280
审稿时长
1 months
期刊介绍: Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.
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