同轴电纺纳米纤维膜作为双功能仿生肌腱鞘用于肌腱修复和抗肌腱膜下粘连

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Qiao Yang, Jianfeng Li, Hongfang Meng, Yongdi Wang, Lanlan Hu, Weiwei Su, Jie Xu, Juedong Hou, Rui Zhao, Zihan Wang, Kairui Zhang, Yaobin Wu, Ling Wang
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引用次数: 0

摘要

肌腱损伤通常表现出有限的愈合能力,并经常因腱周粘连而复杂化,这给临床肌腱修复带来了巨大挑战。虽然目前基于生物材料的膜为肌腱治疗提供了一种前景广阔的策略,但其临床应用却受到炎症引起的粘连的阻碍。在此,本研究提出了一种基于同轴电纺纳米纤维膜的双功能仿生肌腱鞘,用于增强肌腱修复,同时防止腱周粘连。这种纳米纤维膜采用同轴电纺方法制成,将塞来昔布负载的聚己内酯(PCL)包裹在明胶甲基丙烯酰(GelMA)外壳中。体外和体内分析结果表明,这种同轴仿生肌腱鞘能增强肌腱干/祖细胞(TSPCs)的腱源性分化,因为纳米纤维状的GelMA外壳提供了合适的微环境表面。同时,从核心中持续释放的塞来昔布(CEL)能够显著降低炎性细胞因子的表达。值得注意的是,在髌骨肌腱缺损的动物模型中进行的体内评估显示,腱周粘连明显减少,从而进一步促进了肌腱的修复。这些结果凸显了同轴纳米纤维膜作为双功能生物仿真腱鞘的潜力,为肌腱损伤的长期治疗提供了一条前景广阔的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coaxial Electrospun Nanofibrous Membranes as Dual-Functional Biomimetic Tendon Sheath for Tendon Repair and Anti-Peritendinous Adhesion.

Tendon injuries often exhibit limited healing capacity, frequently complicated by peritendinous adhesion, posing a substantial challenge in clinical tendon repair. Although present biomaterial-based membranes offer a promising strategy for tendon treatment, their clinical application is hindered by inflammation-induced adhesion. Herein, this study presents a dual-functional biomimetic tendon sheath based on a coaxial electrospun nanofibrous membrane for enhancing tendon repair and simultaneously preventing peritendinous adhesion. This nanofibrous membrane is fabricated using a coaxial electrospinning method, encapsulating celecoxib-loaded polycaprolactone (PCL) within gelatin methacryloyl (GelMA) shell. Both in vitro and in vivo analysis results demonstrated that such coaxial biomimetic tendon sheath enhanced tenogenic differentiation of tendon stem/progenitor cells (TSPCs) due to nanofibrous GelMA shell providing a suitable microenvironment surface. Simultaneously, the sustained release of celecoxib (CEL) from the core is able to significantly decrease the expression of inflammatory cytokines. Notably, in vivo assessments in animal models with patellar tendon defects revealed significant reductions in peritendinous adhesion, leading to further enhancement in tendon repair. These results underscore the potential of the coaxial nanofibrous membrane as a dual-functional biomimetic tendon sheath, offering a promising avenue for the long-term management of tendon injuries.

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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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