铑（III）催化的 2-芳基-3H-吲哚的直接 C-H 活化：4-庚芳基吡唑的合成策略。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-11-06 DOI:10.1039/d4ob01655f

Zi Yang , Ji Luo , Wenbo Zhang , Jieni Lei , Chaoshui Liu , Yaqian Li

引用次数: 0

摘要

通过铑(III)催化的 C-H 键活化，一种从容易获得的 2-芳基-3H-吲哚和重氮吡唑酮合成 4-杂芳基吡唑的新方案得以实现。这种氧化还原中性策略具有强大的反应活性，可容忍各种官能团，并能在温和的反应条件下以中等产率进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rhodium(iii)-catalyzed direct C–H activation of 2-aryl-3H-indoles: a strategy for 4-heteroaryl pyrazole synthesis†

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Rhodium(iii)-catalyzed direct C–H activation of 2-aryl-3H-indoles: a strategy for 4-heteroaryl pyrazole synthesis†

A novel protocol for synthesizing 4-heteroaryl pyrazoles from readily available 2-aryl-3H-indoles and diazopyrazolones through the rhodium(iii)-catalyzed C–H bond activation has been achieved. This redox-neutral strategy features powerful reactivity, tolerates various functional groups, and proceeds with moderate yields under mild reaction conditions.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.