{"title":"铱催化的串联烯化/aza-迈克尔反应:快速获得 N-N 官能化肼。","authors":"Chao Zhang , Lin Dong","doi":"10.1039/d4ob01631a","DOIUrl":null,"url":null,"abstract":"<div><div>An Ir-catalyzed tandem olefination/aza-Michael reaction of protected benzoylhydrazine derivatives with olefins under mild conditions has been developed. This method can be successfully applied to the construction of various structurally N–N-functionalized hydrazide derivatives bearing the α,β-unsaturated side chain in good to excellent yields. In particular, the deaminoprotected products can be used as potential precursors for the construction of N–N axially chiral compounds.</div></div>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":"23 3","pages":"Pages 673-678"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Iridium-catalyzed tandem olefination/aza-Michael reaction: rapid access to N–N functionalized hydrazides†\",\"authors\":\"Chao Zhang , Lin Dong\",\"doi\":\"10.1039/d4ob01631a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>An Ir-catalyzed tandem olefination/aza-Michael reaction of protected benzoylhydrazine derivatives with olefins under mild conditions has been developed. This method can be successfully applied to the construction of various structurally N–N-functionalized hydrazide derivatives bearing the α,β-unsaturated side chain in good to excellent yields. In particular, the deaminoprotected products can be used as potential precursors for the construction of N–N axially chiral compounds.</div></div>\",\"PeriodicalId\":96,\"journal\":{\"name\":\"Organic & Biomolecular Chemistry\",\"volume\":\"23 3\",\"pages\":\"Pages 673-678\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic & Biomolecular Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1477052024010401\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1477052024010401","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
摘要
我们开发了一种在温和条件下由 Ir 催化的受保护苯甲酰肼衍生物与烯烃的串联烯化/氮杂迈克尔反应。该方法可成功用于构建各种带有 α、β-不饱和侧链的 N-N 功能化酰肼衍生物,收率良好甚至极佳。特别是,脱氨基保护产物可用作构建 N-N 轴手性化合物的潜在前体。
Iridium-catalyzed tandem olefination/aza-Michael reaction: rapid access to N–N functionalized hydrazides†
An Ir-catalyzed tandem olefination/aza-Michael reaction of protected benzoylhydrazine derivatives with olefins under mild conditions has been developed. This method can be successfully applied to the construction of various structurally N–N-functionalized hydrazide derivatives bearing the α,β-unsaturated side chain in good to excellent yields. In particular, the deaminoprotected products can be used as potential precursors for the construction of N–N axially chiral compounds.
期刊介绍:
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.