铱催化的串联烯化/aza-迈克尔反应:快速获得 N-N 官能化肼。

IF 2.7 3区 化学 Q1 CHEMISTRY, ORGANIC
Chao Zhang , Lin Dong
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引用次数: 0

摘要

我们开发了一种在温和条件下由 Ir 催化的受保护苯甲酰肼衍生物与烯烃的串联烯化/氮杂迈克尔反应。该方法可成功用于构建各种带有 α、β-不饱和侧链的 N-N 功能化酰肼衍生物,收率良好甚至极佳。特别是,脱氨基保护产物可用作构建 N-N 轴手性化合物的潜在前体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Iridium-catalyzed tandem olefination/aza-Michael reaction: rapid access to N–N functionalized hydrazides†

Iridium-catalyzed tandem olefination/aza-Michael reaction: rapid access to N–N functionalized hydrazides†
An Ir-catalyzed tandem olefination/aza-Michael reaction of protected benzoylhydrazine derivatives with olefins under mild conditions has been developed. This method can be successfully applied to the construction of various structurally N–N-functionalized hydrazide derivatives bearing the α,β-unsaturated side chain in good to excellent yields. In particular, the deaminoprotected products can be used as potential precursors for the construction of N–N axially chiral compounds.
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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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