铱催化的串联烯化/aza-迈克尔反应：快速获得 N-N 官能化肼。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-11-27 DOI:10.1039/d4ob01631a

Chao Zhang, Lin Dong

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引用次数: 0

摘要

我们开发了一种在温和条件下由 Ir 催化的受保护苯甲酰肼衍生物与烯烃的串联烯化/氮杂迈克尔反应。该方法可成功用于构建各种带有 α、β-不饱和侧链的 N-N 功能化酰肼衍生物，收率良好甚至极佳。特别是，脱氨基保护产物可用作构建 N-N 轴手性化合物的潜在前体。

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Iridium-catalyzed tandem olefination/aza-Michael reaction: rapid access to N-N functionalized hydrazides.

An Ir-catalyzed tandem olefination/aza-Michael reaction of protected benzoylhydrazine derivatives with olefins under mild conditions has been developed. This method can be successfully applied to the construction of various structurally N-N-functionalized hydrazide derivatives bearing the α,β-unsaturated side chain in good to excellent yields. In particular, the deaminoprotected products can be used as potential precursors for the construction of N-N axially chiral compounds.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： The international home of synthetic, physical and biomolecular organic chemistry.