人类精子生物库：概述

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research Pub Date : 2024-11-26 DOI:10.1016/j.arcmed.2024.103130

Alfredo Góngora , William V. Holt , Jaime Gosálvez

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引用次数: 0

摘要

本文旨在详细分析精子冷冻保存的优缺点，重点关注冷冻过程中发生的细胞和分子变化。主要问题是冰晶形成和渗透失衡造成的细胞损伤，以及其他次要影响，如精子活力和存活率，以及顶体反应或氧化应激。另一个重要方面是研究染色质结构和 DNA 的完整性如何影响精子。此外，还分析了影响酶活性和蛋白质稳定性的生化变化。最后，文章重点介绍了旨在减少精子冷冻造成的损害的新兴技术，以及生物库作为解决男性不育问题的重要资源的潜在益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sperm human biobanking: An overview

The purpose of this article is to analyze in detail the advantages and disadvantages of sperm cryopreservation, focusing on the cellular and molecular changes that occur during these processes. The main issue is the cellular damage caused by ice crystal formation and osmotic imbalance, along with other secondary effects such as sperm motility and viability, as well as the acrosome reaction or oxidative stress. Another important aspect is the examination of how chromatin structure and DNA integrity affect sperm. Biochemical changes affecting enzyme activity and protein stability have also been analyzed. Finally, the article highlights emerging technologies aimed at reducing the damage caused by sperm cryopreservation, as well as the potential benefits of biobanks as an essential resource for addressing male infertility.

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来源期刊

Archives of Medical Research 医学-医学：研究与实验

CiteScore

12.50

自引率

0.00%

发文量

审稿时长

28 days

期刊介绍： Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.