Rami M. Mukbel, Abdelqader A. Kreishan, Haifa B. Hammad, Mohammad N.S. Al-Sabi
{"title":"约旦三省六家牧场绵羊抗蠕虫药耐药性的首次报告","authors":"Rami M. Mukbel, Abdelqader A. Kreishan, Haifa B. Hammad, Mohammad N.S. Al-Sabi","doi":"10.1016/j.vprsr.2024.101171","DOIUrl":null,"url":null,"abstract":"<div><div>This study aimed to identify the presence of gastrointestinal nematode populations resistant to albendazole, levamisole, and ivermectin in six farms located in three regions of Jordan (Irbid, Mafraq, and Ma'an). Infected sheep (40 per farm) with at least 100 eggs per gram were randomly divided into four groups (10 animals per group). Three groups were treated with ivermectin, albendazole, or levamisole while the fourth group was used as a negative control group. The standard faecal egg count reduction test (FECRT) was used to assess the drugs' efficacy. Resistance to ivermectin and albendazole was detected in all studied farms while resistance to levamisole was detected in four of the sampled farms. FECRT ranged from 55.6 % (90 % Confidence Intervals (CI): 29.6 % - 79.6 %) to 80.3 % (CI: 48.3 % - 92.1 %) for ivermectin, 77.4 % (CI: 53.2–86.7 %) to 95 % (CI: 85.8–97.6 %) for albendazole, and 86 % (CI: 46.1–95.6 %) to 99.4 % (CI: 97.6–99.7 %) for levamisole. Post-treatment copro-cultures, faecal floatation and/or Baermann technique indicated the presence of larvae of <em>Haemonchus</em> spp. in all of the sampled farms, followed by <em>Nematodirus</em> spp. in four farms, <em>Trichostrongylus</em> spp. in three farms, then <em>Marshallagia</em> spp. in one farm. This is the first study of its kind in Jordan that shows widespread anthelmintic resistance for gastrointestinal nematodes in geographically distant sheep farms in Jordan. Such widespread resistance to anthelmintics imposes a risk of failure to the present control programs and urges for changing the methodology of selecting effective anthelmintic treatments in local farms.</div></div>","PeriodicalId":23600,"journal":{"name":"Veterinary parasitology, regional studies and reports","volume":"57 ","pages":"Article 101171"},"PeriodicalIF":1.4000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"First report of anthelmintic resistance among sheep in six farms from three governorates in Jordan\",\"authors\":\"Rami M. Mukbel, Abdelqader A. Kreishan, Haifa B. Hammad, Mohammad N.S. Al-Sabi\",\"doi\":\"10.1016/j.vprsr.2024.101171\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study aimed to identify the presence of gastrointestinal nematode populations resistant to albendazole, levamisole, and ivermectin in six farms located in three regions of Jordan (Irbid, Mafraq, and Ma'an). Infected sheep (40 per farm) with at least 100 eggs per gram were randomly divided into four groups (10 animals per group). Three groups were treated with ivermectin, albendazole, or levamisole while the fourth group was used as a negative control group. The standard faecal egg count reduction test (FECRT) was used to assess the drugs' efficacy. Resistance to ivermectin and albendazole was detected in all studied farms while resistance to levamisole was detected in four of the sampled farms. FECRT ranged from 55.6 % (90 % Confidence Intervals (CI): 29.6 % - 79.6 %) to 80.3 % (CI: 48.3 % - 92.1 %) for ivermectin, 77.4 % (CI: 53.2–86.7 %) to 95 % (CI: 85.8–97.6 %) for albendazole, and 86 % (CI: 46.1–95.6 %) to 99.4 % (CI: 97.6–99.7 %) for levamisole. Post-treatment copro-cultures, faecal floatation and/or Baermann technique indicated the presence of larvae of <em>Haemonchus</em> spp. in all of the sampled farms, followed by <em>Nematodirus</em> spp. in four farms, <em>Trichostrongylus</em> spp. in three farms, then <em>Marshallagia</em> spp. in one farm. This is the first study of its kind in Jordan that shows widespread anthelmintic resistance for gastrointestinal nematodes in geographically distant sheep farms in Jordan. Such widespread resistance to anthelmintics imposes a risk of failure to the present control programs and urges for changing the methodology of selecting effective anthelmintic treatments in local farms.</div></div>\",\"PeriodicalId\":23600,\"journal\":{\"name\":\"Veterinary parasitology, regional studies and reports\",\"volume\":\"57 \",\"pages\":\"Article 101171\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-11-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary parasitology, regional studies and reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405939024002077\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary parasitology, regional studies and reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405939024002077","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PARASITOLOGY","Score":null,"Total":0}
First report of anthelmintic resistance among sheep in six farms from three governorates in Jordan
This study aimed to identify the presence of gastrointestinal nematode populations resistant to albendazole, levamisole, and ivermectin in six farms located in three regions of Jordan (Irbid, Mafraq, and Ma'an). Infected sheep (40 per farm) with at least 100 eggs per gram were randomly divided into four groups (10 animals per group). Three groups were treated with ivermectin, albendazole, or levamisole while the fourth group was used as a negative control group. The standard faecal egg count reduction test (FECRT) was used to assess the drugs' efficacy. Resistance to ivermectin and albendazole was detected in all studied farms while resistance to levamisole was detected in four of the sampled farms. FECRT ranged from 55.6 % (90 % Confidence Intervals (CI): 29.6 % - 79.6 %) to 80.3 % (CI: 48.3 % - 92.1 %) for ivermectin, 77.4 % (CI: 53.2–86.7 %) to 95 % (CI: 85.8–97.6 %) for albendazole, and 86 % (CI: 46.1–95.6 %) to 99.4 % (CI: 97.6–99.7 %) for levamisole. Post-treatment copro-cultures, faecal floatation and/or Baermann technique indicated the presence of larvae of Haemonchus spp. in all of the sampled farms, followed by Nematodirus spp. in four farms, Trichostrongylus spp. in three farms, then Marshallagia spp. in one farm. This is the first study of its kind in Jordan that shows widespread anthelmintic resistance for gastrointestinal nematodes in geographically distant sheep farms in Jordan. Such widespread resistance to anthelmintics imposes a risk of failure to the present control programs and urges for changing the methodology of selecting effective anthelmintic treatments in local farms.
期刊介绍:
Veterinary Parasitology: Regional Studies and Reports focuses on aspects of veterinary parasitology that are of regional concern, which is especially important in this era of climate change and the rapid and often unconstrained travel of people and animals. Relative to regions, this journal will accept papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites within the field of veterinary medicine. Also, case reports will be considered as they add to information related to local disease and its control; such papers must be concise and represent appropriate medical intervention. Papers on veterinary parasitology from wildlife species are acceptable, but only if they relate to the practice of veterinary medicine. Studies on vector-borne bacterial and viral agents are suitable, but only if the paper deals with vector transmission of these organisms to domesticated animals. Studies dealing with parasite control by means of natural products, both in vivo and in vitro, are more suited for one of the many journals that now specialize in papers of this type. However, due to the regional nature of much of this research, submissions may be considered based upon a case being made by the author(s) to the Editor. Circumstances relating to animal experimentation must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences (obtainable from: Executive Secretary C.I.O.M.S., c/o W.H.O., Via Appia, CH-1211 Geneva 27, Switzerland).