双硫仑和癌症免疫疗法:先进的纳米给药系统和潜在的治疗策略

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Di Huang , Yinsha Yao , Yifei Lou , Longfa Kou , Qing Yao , Ruijie Chen
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引用次数: 0

摘要

双硫仑临床应用的最初重点是其治疗酒精中毒的功效。不过,最近的研究发现,它具有抗肿瘤剂甚至是癌症免疫疗法增强剂的潜力。双硫仑已获得美国食品及药物管理局的安全认证,这表明它比其他用于疾病治疗的物质更安全。虽然已经开展了涉及双硫仑或其与其他抗肿瘤药物组合的临床试验,但治疗结果并不令人满意,因此强调了解决药物递送这一关键挑战的重要性。探索先进的纳米给药系统以及双硫仑在癌症治疗中潜在的免疫疗法增强效果的需求日益增加。本综述重点介绍了双硫仑抗击癌症的各种方法,尤其是激活免疫相关机制的方法。综述还讨论了与双硫仑给药相关的障碍,并提供了现有的给药解决方案。这些给药策略为解决不同给药方法中遇到的各种难题提供了解决方案,旨在实现更强的治疗效果。重点是双硫仑给药策略的最新进展以及双硫仑在免疫调节方面的未来潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies

Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
The initial focus of the clinical application of disulfiram was its efficacy in treating alcoholism. However, recent research has revealed its potential as an anti-tumor agent and even as an enhancer of cancer immunotherapy. Disulfiram has received safety approval from the FDA, indicating its safety advantages over other substances used for disease treatment. Although clinical trials have been conducted on strategies involving disulfiram or its combination with other anti-tumor drugs, the treatment outcomes have not yielded satisfactory results, thereby emphasizing the significance of addressing drug delivery as a crucial challenge to be resolved. The need to explore advanced nano-delivery systems and the potential immunotherapy enhancement effect of disulfiram in cancer treatment has increased. This review highlights various ways in which disulfiram can combat cancer and importantly, activate immune-related mechanisms. It also discusses obstacles related to delivering disulfiram and provides existing solutions in terms of drug delivery. These drug delivery strategies offer solutions to address various challenges encountered in diverse delivery methods and aim to achieve enhanced therapeutic effects. The focus is on recent advancements in disulfiram delivery strategies and the future potential of disulfiram in immune regulation.
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来源期刊
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
6.60
自引率
0.00%
发文量
32
审稿时长
24 days
期刊介绍: International Journal of Pharmaceutics: X offers authors with high-quality research who want to publish in a gold open access journal the opportunity to make their work immediately, permanently, and freely accessible. International Journal of Pharmaceutics: X authors will pay an article publishing charge (APC), have a choice of license options, and retain copyright. Please check the APC here. The journal is indexed in SCOPUS, PUBMED, PMC and DOAJ. The International Journal of Pharmaceutics is the second most cited journal in the "Pharmacy & Pharmacology" category out of 358 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.
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