用于生物和水样中酮康唑传感的表面接枝 MoS₂

IF 4.9 2区 化学 Q2 CHEMISTRY, PHYSICAL
Krishnapandi Alagumalai , Balamurugan Muthukutty , Mani Sivakumar , Daeho Lee , Seong-Cheol Kim
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引用次数: 0

摘要

真菌感染需要使用重要的抗真菌药物,然而,尽管这些药物很有效,但它们会诱发严重的反应,与各种药物相互作用,并对环境产生有害影响。因此,人们迫切需要准确、灵敏、可靠的检测方法来减轻甚至避免这些潜在的负面影响。有鉴于此,本研究采用液相剥离水热法研究了一种生物相容性β-环糊精(β-CD)功能化二硫化钼(MoS2)纳米复合材料。通过改性玻璃碳电极 (GCE),对 β-CD/MoS2 的酮康唑 (KTZ) 电化学检测能力进行了评估。利用各种分析和光谱技术,如 X 射线晶体学 (XRD)、X 射线光电子能谱 (XPS)、场发射扫描电子显微镜 (FE-SEM) 和透射电子显微镜 (TEM) 分析,对合成的 β-CD/MoS2 进行了全面的表征。此外,β-CD/MoS2 传感器还在不同条件下(包括扫描速率和 pH 值变化)进行了测试,成功地检测到了浓度低至 1.0 nM 的 KTZ。它的灵敏度高达 1.3567 µA µM-1 cm-2,定量限(LOQ)为 0.4 nM,在传感性能上超越了其他电极。所提出的传感器被成功地应用于检测药物制剂和生物样品中的 KTZ,并取得了良好的回收率。此外,在存在其他共干扰的情况下,该传感器对 KTZ 的检测具有高选择性、良好的重复性和再现性以及较高的储存稳定性。因此,该方法证明是实用的,而且不会对 KTZ 传感器产生任何基质效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Surface-grafted MoS₂ for ketoconazole sensing in biological and aqua samples
Fungal infections necessitate crucial antifungal agents, yet despite their effectiveness, these drugs can induce severe reactions, interact with various medications, and have detrimental environmental effects. Consequently, there is a pressing need for accurate, sensitive, and reliable detection methods to mitigate and ideally prevent these potential negative impacts. Due to that, the present work is devoted to a biocompatible β−cyclodextrin (β−CD) functionalized molybdenum disulfide (MoS2) nanocomposite using a liquid exfoliated hydrothermal method. β−CD/MoS2 was assessed for its electrochemical detection capabilities of ketoconazole (KTZ) by modifying the glassy carbon electrode (GCE). The synthesized β−CD/MoS2 undergoes thorough characterization using various analytical and spectroscopic techniques, such as X−ray crystallography (XRD), X-ray photoelectron spectroscopy (XPS), Field emission scanning electron microscopy (FE−SEM), and Transmission electron microscopy (TEM) analysis. Furthermore, the β−CD/MoS2 sensor is tested under diverse conditions, including scan rate and pH variations, successfully detecting KTZ at concentrations as low as 1.0 nM. It demonstrates an impressive sensitivity of 1.3567 µA µM−1 cm−2 and a limit of quantification (LOQ) matching at 0.4 nM, surpassing other electrodes in sensing performance. The proposed sensor was successfully applied to determine KTZ in pharmaceutical formulations and biological samples with good recoveries. In addition, the sensor displayed the high selective detection of KTZ in the existence of other co-interferences, good repeatability, reproducibility, and high storage stability. As a result, this method proves to be practical and devoid of any matrix effect on the KTZ sensor.
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来源期刊
CiteScore
8.70
自引率
9.60%
发文量
2421
审稿时长
56 days
期刊介绍: Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.
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