基于壳聚糖和明胶的可喷涂水凝胶,结合了光热和长效抗生素杀菌技术,可用于感染性伤口管理,并具有形状适应性

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED
Fei Wang , Xing Wang , Siwei Li , Qisen Yang , Haibo Mu , Jinyao Li , Yu Yang
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引用次数: 0

摘要

急性创伤造成的严重皮肤损伤往往伴随着出血失控、微生物感染和伤口延迟愈合。本文将抗菌纳米平台(CT-CS-ZIF@CIP)融入由甲基丙烯酸壳聚糖和没食子酸接枝明胶组成的光固化凝胶中,开发出了用于伤口管理的多功能可喷涂水凝胶(CT-CS-ZIF@CIP凝胶)。该纳米平台最初是通过将 Cu2Se(CS)和环丙沙星装饰的沸石咪唑酸框架-8(ZIF@CIP)依次装载到掺铜的 Ti MOF(CT)上而构建的,其中,CS 可作为光热剂,ZIF 可实现 CIP 的 pH 响应释放,CT 可作为 CS 和 ZIF@CIP 的载体。水凝胶前体可喷洒到伤口表面并快速光固化,使水凝胶与伤口形状相适应,并在伤口现场形成保护屏障。制成的水凝胶具有出色的止血能力、粘附性、细胞相容性和毒素吸附能力。通过将用于短期光热疗法的 CS 与用于长效化疗的 CIP 相结合,CT-CS-ZIF@CIP 凝胶对三种细菌菌株的杀菌率达到了 100%。此外,锌和铜离子的适度释放促进了伤口愈合。水凝胶的疗效在受感染的皮肤小鼠模型中得到了验证。总之,这项研究提出了一种多功能可喷涂水凝胶,可灵活应用于不规则的动态伤口,从而实现安全有效的伤口管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Chitosan and gelatin based sprayable hydrogels incorporating photothermal and long-acting antibiotic sterilization for infected wound management with shape adaptability

Chitosan and gelatin based sprayable hydrogels incorporating photothermal and long-acting antibiotic sterilization for infected wound management with shape adaptability
Severe skin damage resulting from acute trauma is often accompanied by uncontrolled bleeding, microbial infections, and delayed wound healing. Herein, multifunctional sprayable hydrogels (CT-CS-ZIF@CIP Gel) were developed for wound management by incorporating antibacterial nanoplatforms (CT-CS-ZIF@CIP) into photocurable gels consisting of chitosan methacrylate and gallic acid grafted gelatin. The nanoplatform was initially constructed by sequentially loading Cu2Se (CS) and ciprofloxacin-decorated zeolitic imidazolate framework-8 (ZIF@CIP) onto Cu-doped Ti MOF (CT), in which CS served as a photothermal agent, ZIF enabled pH-responsive release of CIP, and CT acted as carriers for CS and ZIF@CIP. The hydrogel precursor can be sprayed onto wound surface and photocured quickly, allowing hydrogel to fit the wound shape and form a protective barrier onsite. The resultant hydrogel exhibited excellent hemostatic ability, adhesion properties, cytocompatibility and toxin adsorption capacity. By integrating CS for short-term photothermal therapy with CIP for long-acting chemotherapy, the CT-CS-ZIF@CIP Gel demonstrated 100 % sterilization of three bacterial strains. Furthermore, moderate release of zinc and copper ions promoted wound healing. The therapeutic efficacy of hydrogel was validated in an infected cutaneous mouse model. Overall, this work presents a versatile sprayable hydrogel that can be flexibly applied to irregular dynamic wounds for safe and effective wound management.
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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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