{"title":"含有表没食子儿茶素-3-棓酸盐的多功能羧甲基壳聚糖基海绵可加速全厚烧伤糖尿病大鼠的伤口愈合","authors":"Yanting Wang, Ziming Zhu, Xiansen Lv, Baoqin Han, Zhiwen Jiang","doi":"10.1016/j.carbpol.2024.123025","DOIUrl":null,"url":null,"abstract":"<div><div>Full-thickness burn wounds in diabetes often present significant challenges in terms of timely progression of healing and even mortality. Multifunctional dressings that possess strong absorptivity and mechanical property while effectively regulating inflammation and promoting angiogenesis is therefore crucial. We have developed a novel sponge (CCGE) comprising carboxymethyl chitosan, gelatin, and glycerin for the purpose of promoting accelerated healing of scald wounds in diabetic rats. This sponge is loaded with epigallocatechin-3-gallate, which possesses antioxidant and anti-inflammatory properties. The incorporation of the crosslinker BDDE reinforces its mechanical characteristics by augmenting the interplay between the sponge structure through hydrogen bonding and covalent bonding. Moreover, the crosslinked sponges provide a highly absorptive layer, carboxymethyl chitosan show good biocompatibility and angiogenic effects, and the gelatin provide matrix metalloproteinases-9 targeting. The CCGE sponges exhibit high biocompatibility, facilitate fibroblast migration, and promote tube formation. The application of the CCGE sponges significantly accelerates wound healing of full-thickness scald wounds in diabetic rats, exhibits enhanced collagen synthesis, reduced levels of pro-inflammatory cytokines, and increased blood vessel formation within the wounded area. In summary, this study presents a multifunctional composite CCGE sponge dressing that effectively modulates ROS, inflammation, and angiogenesis to facilitate comprehensive burn wound tissue repair in diabetes.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 123025"},"PeriodicalIF":10.7000,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multifunctional carboxymethyl chitosan-based sponges loaded with epigallocatechin-3-gallate for accelerating wound healing in diabetic rats with full-thickness burns\",\"authors\":\"Yanting Wang, Ziming Zhu, Xiansen Lv, Baoqin Han, Zhiwen Jiang\",\"doi\":\"10.1016/j.carbpol.2024.123025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Full-thickness burn wounds in diabetes often present significant challenges in terms of timely progression of healing and even mortality. Multifunctional dressings that possess strong absorptivity and mechanical property while effectively regulating inflammation and promoting angiogenesis is therefore crucial. We have developed a novel sponge (CCGE) comprising carboxymethyl chitosan, gelatin, and glycerin for the purpose of promoting accelerated healing of scald wounds in diabetic rats. This sponge is loaded with epigallocatechin-3-gallate, which possesses antioxidant and anti-inflammatory properties. The incorporation of the crosslinker BDDE reinforces its mechanical characteristics by augmenting the interplay between the sponge structure through hydrogen bonding and covalent bonding. Moreover, the crosslinked sponges provide a highly absorptive layer, carboxymethyl chitosan show good biocompatibility and angiogenic effects, and the gelatin provide matrix metalloproteinases-9 targeting. The CCGE sponges exhibit high biocompatibility, facilitate fibroblast migration, and promote tube formation. The application of the CCGE sponges significantly accelerates wound healing of full-thickness scald wounds in diabetic rats, exhibits enhanced collagen synthesis, reduced levels of pro-inflammatory cytokines, and increased blood vessel formation within the wounded area. In summary, this study presents a multifunctional composite CCGE sponge dressing that effectively modulates ROS, inflammation, and angiogenesis to facilitate comprehensive burn wound tissue repair in diabetes.</div></div>\",\"PeriodicalId\":261,\"journal\":{\"name\":\"Carbohydrate Polymers\",\"volume\":\"350 \",\"pages\":\"Article 123025\"},\"PeriodicalIF\":10.7000,\"publicationDate\":\"2024-11-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Carbohydrate Polymers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0144861724012517\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate Polymers","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0144861724012517","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Multifunctional carboxymethyl chitosan-based sponges loaded with epigallocatechin-3-gallate for accelerating wound healing in diabetic rats with full-thickness burns
Full-thickness burn wounds in diabetes often present significant challenges in terms of timely progression of healing and even mortality. Multifunctional dressings that possess strong absorptivity and mechanical property while effectively regulating inflammation and promoting angiogenesis is therefore crucial. We have developed a novel sponge (CCGE) comprising carboxymethyl chitosan, gelatin, and glycerin for the purpose of promoting accelerated healing of scald wounds in diabetic rats. This sponge is loaded with epigallocatechin-3-gallate, which possesses antioxidant and anti-inflammatory properties. The incorporation of the crosslinker BDDE reinforces its mechanical characteristics by augmenting the interplay between the sponge structure through hydrogen bonding and covalent bonding. Moreover, the crosslinked sponges provide a highly absorptive layer, carboxymethyl chitosan show good biocompatibility and angiogenic effects, and the gelatin provide matrix metalloproteinases-9 targeting. The CCGE sponges exhibit high biocompatibility, facilitate fibroblast migration, and promote tube formation. The application of the CCGE sponges significantly accelerates wound healing of full-thickness scald wounds in diabetic rats, exhibits enhanced collagen synthesis, reduced levels of pro-inflammatory cytokines, and increased blood vessel formation within the wounded area. In summary, this study presents a multifunctional composite CCGE sponge dressing that effectively modulates ROS, inflammation, and angiogenesis to facilitate comprehensive burn wound tissue repair in diabetes.
期刊介绍:
Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience.
The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.