来自脑炎患者的多种抗NMDAR自身抗体

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-11-27 DOI:10.1038/s41594-024-01435-y

Zoe Jamet, Frederic Villega, Laurent Groc

引用次数: 0

摘要

在抗NMDAR脑炎患者中发现了针对谷氨酸能N-甲基-d-天冬氨酸受体（NMDAR）的自身抗体。两项研究显示，患者来源的自身抗体在表位结合和对 NMDAR 的作用模式上具有多样性，这为了解自身抗体诱导 NMDAR 功能低下背后的机制提供了启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Diverse anti-NMDAR autoantibodies from individuals with encephalitis

查看原文本刊更多论文

Diverse anti-NMDAR autoantibodies from individuals with encephalitis

Autoantibodies targeting glutamatergic N-methyl-d-aspartic acid receptors (NMDARs) are found in people with anti-NMDAR encephalitis. Two studies reveal that patient-derived autoantibodies are diverse in their epitope binding and modes of action on the NMDAR, providing insights into the mechanisms behind autoantibody-induced NMDAR hypofunction.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.