使用 FCSEMS（SPHINX）进行括约肌切开术：不朽的答案还是新谜团的开端？

IF 23 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pub Date : 2024-11-26 DOI:10.1136/gutjnl-2024-334224

Mohan Ramchandani, Aniruddha Pratap Singh, Rupjyoti Talukdar, D Nageshwar Reddy

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引用次数: 0

摘要

我们饶有兴趣地阅读了最近发表的随机对照试验 (RCT) "SPHINX "1，该试验探讨了内镜下括约肌切开术 (ES) 并放置全覆盖金属支架 (FCSEMS) 在预防胃食管反流术后胰腺炎 (PEP) 中的作用。尽管这是有关该主题的最大 RCT，但仍有几个问题值得讨论。已发表的数据显示，SEMS 术后胰腺炎的发生率从 0% 到 26.8% 不等2-4，而胰腺炎的预防措施也存在很大的异质性。尽管如此，重症胰腺炎仍然很少见。要评估 ES 的影响，需要更大的样本量。SPHINX 试验的样本 ...

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Sphincterotomy with FCSEMS (SPHINX): a monumental answer or the beginning of new mysteries?

We read with interest the recently published randomised controlled trial (RCT) ‘SPHINX’,1 addressing the role of endoscopic sphincterotomy (ES) with fully covered s metal stent (FCSEMS) placement in preventing post-ERCP pancreatitis (PEP). Although this is the largest RCT on the topic, several concerns warrant discussion. Published data report variable rates of PEP after SEMS ranging from 0% to 26.8%,2–4 with lot of heterogeneity regarding the PEP preventive measures. Nevertheless severe pancreatitis remains rare. To assess the impact of ES a larger sample size will be required. The SPHINX trial sample …

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来源期刊

Gut 医学-胃肠肝病学

CiteScore

45.70

自引率

2.40%

发文量

284

审稿时长

1.5 months

期刊介绍： Gut is a renowned international journal specializing in gastroenterology and hepatology, known for its high-quality clinical research covering the alimentary tract, liver, biliary tree, and pancreas. It offers authoritative and current coverage across all aspects of gastroenterology and hepatology, featuring articles on emerging disease mechanisms and innovative diagnostic and therapeutic approaches authored by leading experts. As the flagship journal of BMJ's gastroenterology portfolio, Gut is accompanied by two companion journals: Frontline Gastroenterology, focusing on education and practice-oriented papers, and BMJ Open Gastroenterology for open access original research.