Tingting Yang, Kylie E Beach, Chendi Zhu, Mingyu Gan, Wenli Wang, Hongjuan Zhou, Lijun Peng, Shanshan Wang, Long Cai, Weimin Li, Jordan B Davis, Nico Cicchetti, E Susan Slechta, Adam Barker, Salika M Shakir, Allison F Carey, Qingyun Liu
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Genomic Analysis of Global Mycobacterium abscessus Isolates Reveals Ongoing Evolution of Drug Resistance-Associated Genes.
Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood. We analyzed published genomes of 5617 clinical MAB isolates from 20 countries and searched for signals of ongoing evolution in 35 drug resistance-associated genes. Of these, we found 14 genes that were subject to positive selection, and we identified novel mutational sites under selection. Among these, the erm(41) V80I mutation arose exclusively in strains with erm(41) 28T and affected 50.5% (1750/3465) of subsp abscessus isolates. The study provided evidence that MAB is evolving mutations in drug resistance-associated genes, and further research is needed to understand the functional consequences of these mutations.
期刊介绍：
Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.
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